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Can vitamin D induce remission in patients with inflammatory bowel disease?

BACKGROUND: The prevalence of vitamin D (VD) deficiency in adults with inflammatory bowel disease (IBD) has been reported to be very high. In adults with ulcerative colitis (UC) it has been estimated to be around 45-50%, and in the case of Crohn’s disease (CD) it ranges from 35-100%. This systematic...

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Autores principales: Goulart, Ricardo de Alvares, Barbalho, Sandra Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922253/
https://www.ncbi.nlm.nih.gov/pubmed/35479590
http://dx.doi.org/10.20524/aog.2022.0692
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author Goulart, Ricardo de Alvares
Barbalho, Sandra Maria
author_facet Goulart, Ricardo de Alvares
Barbalho, Sandra Maria
author_sort Goulart, Ricardo de Alvares
collection PubMed
description BACKGROUND: The prevalence of vitamin D (VD) deficiency in adults with inflammatory bowel disease (IBD) has been reported to be very high. In adults with ulcerative colitis (UC) it has been estimated to be around 45-50%, and in the case of Crohn’s disease (CD) it ranges from 35-100%. This systematic review aimed to address the effects of VD in inducing remission in patients with CD and UC. METHODS: PubMed, Embase, and Cochrane were searched, and PRISMA guidelines were followed. Nine studies with active disease subjects were evaluated; 5 of them investigated patients with UC, 2 studied patients with CD, while 2 studies included patients with both diseases. RESULTS: The studies show that oral daily doses from 1000 IU can raise VD levels above 20 ng/mL in patients with active CD or UC. Doses close to 50,000 IU per week are sufficient to raise VD levels above 40 ng/mL. Moreover, daily doses from 2000 IU can be related to improvements in the clinical scores of the disease and improvement in patients’ quality of life. CONCLUSION: It is challenging to define the best doses of VD as a therapeutic adjunct to induce remission in IBD patients, as there are biases in the inclusion of studies, since the route of administration of the VD can vary, as well as the doses and the time of use.
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spelling pubmed-89222532022-04-26 Can vitamin D induce remission in patients with inflammatory bowel disease? Goulart, Ricardo de Alvares Barbalho, Sandra Maria Ann Gastroenterol Original Article BACKGROUND: The prevalence of vitamin D (VD) deficiency in adults with inflammatory bowel disease (IBD) has been reported to be very high. In adults with ulcerative colitis (UC) it has been estimated to be around 45-50%, and in the case of Crohn’s disease (CD) it ranges from 35-100%. This systematic review aimed to address the effects of VD in inducing remission in patients with CD and UC. METHODS: PubMed, Embase, and Cochrane were searched, and PRISMA guidelines were followed. Nine studies with active disease subjects were evaluated; 5 of them investigated patients with UC, 2 studied patients with CD, while 2 studies included patients with both diseases. RESULTS: The studies show that oral daily doses from 1000 IU can raise VD levels above 20 ng/mL in patients with active CD or UC. Doses close to 50,000 IU per week are sufficient to raise VD levels above 40 ng/mL. Moreover, daily doses from 2000 IU can be related to improvements in the clinical scores of the disease and improvement in patients’ quality of life. CONCLUSION: It is challenging to define the best doses of VD as a therapeutic adjunct to induce remission in IBD patients, as there are biases in the inclusion of studies, since the route of administration of the VD can vary, as well as the doses and the time of use. Hellenic Society of Gastroenterology 2022 2022-01-07 /pmc/articles/PMC8922253/ /pubmed/35479590 http://dx.doi.org/10.20524/aog.2022.0692 Text en Copyright: © Hellenic Society of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Goulart, Ricardo de Alvares
Barbalho, Sandra Maria
Can vitamin D induce remission in patients with inflammatory bowel disease?
title Can vitamin D induce remission in patients with inflammatory bowel disease?
title_full Can vitamin D induce remission in patients with inflammatory bowel disease?
title_fullStr Can vitamin D induce remission in patients with inflammatory bowel disease?
title_full_unstemmed Can vitamin D induce remission in patients with inflammatory bowel disease?
title_short Can vitamin D induce remission in patients with inflammatory bowel disease?
title_sort can vitamin d induce remission in patients with inflammatory bowel disease?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922253/
https://www.ncbi.nlm.nih.gov/pubmed/35479590
http://dx.doi.org/10.20524/aog.2022.0692
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