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The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection
BACKGROUND: Vitamin D and its receptor (VDR) exert important immunoregulatory functions that contribute to liver homeostasis. The aim of this study was to investigate the influence of FokI, ApaI, BsmI and TaqI VDR polymorphisms on cirrhosis development and laboratory variables in patients with chron...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hellenic Society of Gastroenterology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922255/ https://www.ncbi.nlm.nih.gov/pubmed/35479594 http://dx.doi.org/10.20524/aog.2022.0697 |
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author | Tsounis, Efthymios P. Tourkochristou, Evanthia Sapsani, Aggeliki Aggeletopoulou, Ioanna Lourida, Theoni Ζisimopoulos, Κonstantinos Tzikopoulos, Theodoros Diamantopoulou, Georgia Tsintoni, Aggeliki Thomopoulos, Konstantinos Mouzaki, Athanasia Triantos, Christos |
author_facet | Tsounis, Efthymios P. Tourkochristou, Evanthia Sapsani, Aggeliki Aggeletopoulou, Ioanna Lourida, Theoni Ζisimopoulos, Κonstantinos Tzikopoulos, Theodoros Diamantopoulou, Georgia Tsintoni, Aggeliki Thomopoulos, Konstantinos Mouzaki, Athanasia Triantos, Christos |
author_sort | Tsounis, Efthymios P. |
collection | PubMed |
description | BACKGROUND: Vitamin D and its receptor (VDR) exert important immunoregulatory functions that contribute to liver homeostasis. The aim of this study was to investigate the influence of FokI, ApaI, BsmI and TaqI VDR polymorphisms on cirrhosis development and laboratory variables in patients with chronic hepatitis C (CHC). METHODS: A total of 48 patients were enrolled in this retrospective, observational study and underwent genotype analysis; their medical records were examined to obtain relevant data. RESULTS: The cumulative rate of progression to cirrhosis during the course of CHC was 31.3% after a median period of 11 years from diagnosis. Importantly, in multivariate analysis, FokI ff (adjusted hazard ratio [aHR] 13.6, 95% confidence interval [CI] 2.51-73.73; P=0.002) and ApaI aa (aHR 4.69, 95%CI 1.13-19.43; P=0.033) genotypes were independently associated with progression to cirrhosis. The presence of the aa genotype was also associated with higher liver stiffness measurements measured by transient elastography compared to the AA/Aa genotype (12.3kPa interquartile range [IQR] 9.6-17.3 vs. 7.1kPa IQR 5.6-11.1; P=0.012). In addition, higher HCV RNA and lower serum albumin levels were observed in patients with the tt genotype of the TaqI polymorphism compared to TT/Tt carriers, and in patients with the aa genotype compared to AA/Aa carriers. In haplotype analysis, no association was found between any haplotype and disease progression. CONCLUSIONS: In patients with CHC, laboratory parameters are influenced by VDR polymorphisms and the development of cirrhosis is related to homozygosity for the dominant trait of ApaI and FokI variants. |
format | Online Article Text |
id | pubmed-8922255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-89222552022-04-26 The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection Tsounis, Efthymios P. Tourkochristou, Evanthia Sapsani, Aggeliki Aggeletopoulou, Ioanna Lourida, Theoni Ζisimopoulos, Κonstantinos Tzikopoulos, Theodoros Diamantopoulou, Georgia Tsintoni, Aggeliki Thomopoulos, Konstantinos Mouzaki, Athanasia Triantos, Christos Ann Gastroenterol Original Article BACKGROUND: Vitamin D and its receptor (VDR) exert important immunoregulatory functions that contribute to liver homeostasis. The aim of this study was to investigate the influence of FokI, ApaI, BsmI and TaqI VDR polymorphisms on cirrhosis development and laboratory variables in patients with chronic hepatitis C (CHC). METHODS: A total of 48 patients were enrolled in this retrospective, observational study and underwent genotype analysis; their medical records were examined to obtain relevant data. RESULTS: The cumulative rate of progression to cirrhosis during the course of CHC was 31.3% after a median period of 11 years from diagnosis. Importantly, in multivariate analysis, FokI ff (adjusted hazard ratio [aHR] 13.6, 95% confidence interval [CI] 2.51-73.73; P=0.002) and ApaI aa (aHR 4.69, 95%CI 1.13-19.43; P=0.033) genotypes were independently associated with progression to cirrhosis. The presence of the aa genotype was also associated with higher liver stiffness measurements measured by transient elastography compared to the AA/Aa genotype (12.3kPa interquartile range [IQR] 9.6-17.3 vs. 7.1kPa IQR 5.6-11.1; P=0.012). In addition, higher HCV RNA and lower serum albumin levels were observed in patients with the tt genotype of the TaqI polymorphism compared to TT/Tt carriers, and in patients with the aa genotype compared to AA/Aa carriers. In haplotype analysis, no association was found between any haplotype and disease progression. CONCLUSIONS: In patients with CHC, laboratory parameters are influenced by VDR polymorphisms and the development of cirrhosis is related to homozygosity for the dominant trait of ApaI and FokI variants. Hellenic Society of Gastroenterology 2022 2022-02-14 /pmc/articles/PMC8922255/ /pubmed/35479594 http://dx.doi.org/10.20524/aog.2022.0697 Text en Copyright: © Hellenic Society of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Tsounis, Efthymios P. Tourkochristou, Evanthia Sapsani, Aggeliki Aggeletopoulou, Ioanna Lourida, Theoni Ζisimopoulos, Κonstantinos Tzikopoulos, Theodoros Diamantopoulou, Georgia Tsintoni, Aggeliki Thomopoulos, Konstantinos Mouzaki, Athanasia Triantos, Christos The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title | The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title_full | The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title_fullStr | The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title_full_unstemmed | The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title_short | The role of vitamin D receptor polymorphisms in the course of chronic hepatitis C infection |
title_sort | role of vitamin d receptor polymorphisms in the course of chronic hepatitis c infection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922255/ https://www.ncbi.nlm.nih.gov/pubmed/35479594 http://dx.doi.org/10.20524/aog.2022.0697 |
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