Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

[Image: see text] Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuberculosis NDH-2, as well as the gr...

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Detalles Bibliográficos
Autores principales: Lu, Lu, Åkerbladh, Linda, Ahmad, Shabbir, Konda, Vivek, Cao, Sha, Vocat, Anthony, Maes, Louis, Cole, Stewart T., Hughes, Diarmaid, Larhed, Mats, Brandt, Peter, Karlén, Anders, Mowbray, Sherry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922281/
https://www.ncbi.nlm.nih.gov/pubmed/35184552
http://dx.doi.org/10.1021/acsinfecdis.1c00413

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