Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice

Since mid-2016, the low pathogenic H7N9 influenza virus has evolved into a highly pathogenic (HP) phenotype in China, raising many concerns about public health and poultry industry. The insertion of a “KRTA” motif at hemagglutinin cleavage site (HACS) occurred in the early stage of HP H7N9 variants....

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Detalles Bibliográficos
Autores principales: Zhou, Aobaixue, Zhang, Jiahao, Li, Huanan, Xu, Qiang, Chen, Yiqun, Li, Bo, Liu, Wanying, Su, Guanming, Ren, Xingxing, Lao, Guangjie, Luo, Baozheng, Liao, Ming, Qi, Wenbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922421/
https://www.ncbi.nlm.nih.gov/pubmed/35234617
http://dx.doi.org/10.1016/j.virs.2022.01.001

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