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Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea
Diarrhea is the third leading cause of death in developing countries in children under the age of five. About half a million children die of diarrhea every year, most of which in developing countries. Viruses are the main pathogen of diarrhea. In China, the fecal virome of children with diarrhea has...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wuhan Institute of Virology, Chinese Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922427/ https://www.ncbi.nlm.nih.gov/pubmed/35234620 http://dx.doi.org/10.1016/j.virs.2022.01.012 |
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author | Yang, Shixing He, Yumin Zhang, Ju Zhang, Dianqi Wang, Yan Lu, Xiang Wang, Xiaochun Shen, Quan Ji, Likai Lu, Hongyan Zhang, Wen |
author_facet | Yang, Shixing He, Yumin Zhang, Ju Zhang, Dianqi Wang, Yan Lu, Xiang Wang, Xiaochun Shen, Quan Ji, Likai Lu, Hongyan Zhang, Wen |
author_sort | Yang, Shixing |
collection | PubMed |
description | Diarrhea is the third leading cause of death in developing countries in children under the age of five. About half a million children die of diarrhea every year, most of which in developing countries. Viruses are the main pathogen of diarrhea. In China, the fecal virome of children with diarrhea has been rarely studied. Using an unbiased viral metagenomics approach, we analyzed the fecal virome in children with diarrhea. Many DNA or RNA viruses associated with diarrhea identified in those fecal samples were mainly from six families of Adenoviridae, Astroviridae, Caliciviridae, Parvoviridae, Picornaviridae, and Reoviridae. Among them, the family of Caliciviridae accounts for the largest proportion of 78.42%, following with Adenoviridae (8.94%) and Picornaviridae (8.36%). In addition to those diarrhea-related viruses that have already been confirmed to cause human diarrhea, the viruses not associated with diarrhea were also identified including anellovirus and picobirnavirus. This study increased our understanding of diarrheic children fecal virome and provided valuable information for the prevention and treatment of viral diarrhea in this area. |
format | Online Article Text |
id | pubmed-8922427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wuhan Institute of Virology, Chinese Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-89224272022-03-21 Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea Yang, Shixing He, Yumin Zhang, Ju Zhang, Dianqi Wang, Yan Lu, Xiang Wang, Xiaochun Shen, Quan Ji, Likai Lu, Hongyan Zhang, Wen Virol Sin Research Article Diarrhea is the third leading cause of death in developing countries in children under the age of five. About half a million children die of diarrhea every year, most of which in developing countries. Viruses are the main pathogen of diarrhea. In China, the fecal virome of children with diarrhea has been rarely studied. Using an unbiased viral metagenomics approach, we analyzed the fecal virome in children with diarrhea. Many DNA or RNA viruses associated with diarrhea identified in those fecal samples were mainly from six families of Adenoviridae, Astroviridae, Caliciviridae, Parvoviridae, Picornaviridae, and Reoviridae. Among them, the family of Caliciviridae accounts for the largest proportion of 78.42%, following with Adenoviridae (8.94%) and Picornaviridae (8.36%). In addition to those diarrhea-related viruses that have already been confirmed to cause human diarrhea, the viruses not associated with diarrhea were also identified including anellovirus and picobirnavirus. This study increased our understanding of diarrheic children fecal virome and provided valuable information for the prevention and treatment of viral diarrhea in this area. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-01-17 /pmc/articles/PMC8922427/ /pubmed/35234620 http://dx.doi.org/10.1016/j.virs.2022.01.012 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Yang, Shixing He, Yumin Zhang, Ju Zhang, Dianqi Wang, Yan Lu, Xiang Wang, Xiaochun Shen, Quan Ji, Likai Lu, Hongyan Zhang, Wen Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title | Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title_full | Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title_fullStr | Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title_full_unstemmed | Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title_short | Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
title_sort | viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922427/ https://www.ncbi.nlm.nih.gov/pubmed/35234620 http://dx.doi.org/10.1016/j.virs.2022.01.012 |
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