A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo

Zika virus (ZIKV) can infect a wide range of tissues including the developmental brain of human fetus. Whether specific viral genetic variants are linked to neuropathology is incompletely understood. To address this, we have intracranially serially passaged a clinical ZIKV isolate (SW01) in neonatal...

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Detalles Bibliográficos
Autores principales: Liu, Zhihua, Zhang, Yawei, Cheng, Mengli, Ge, Ningning, Shu, Jiayi, Xu, Zhiheng, Su, Xiao, Kou, Zhihua, Tong, Yigang, Qin, Chengfeng, Jin, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922429/
https://www.ncbi.nlm.nih.gov/pubmed/35234632
http://dx.doi.org/10.1016/j.virs.2022.01.021

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