mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope (Env) trimer protein nanoparticles are superior immunogens compared with trimers alone for priming of broadly neutralizing antibo...

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Detalles Bibliográficos
Autores principales: Mu, Zekun, Wiehe, Kevin, Saunders, Kevin O., Henderson, Rory, Cain, Derek W., Parks, Robert, Martik, Diana, Mansouri, Katayoun, Edwards, Robert J., Newman, Amanda, Lu, Xiaozhi, Xia, Shi-Mao, Eaton, Amanda, Bonsignori, Mattia, Montefiori, David, Han, Qifeng, Venkatayogi, Sravani, Evangelous, Tyler, Wang, Yunfei, Rountree, Wes, Korber, Bette, Wagh, Kshitij, Tam, Ying, Barbosa, Christopher, Alam, S. Munir, Williams, Wilton B., Tian, Ming, Alt, Frederick W., Pardi, Norbert, Weissman, Drew, Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922439/
https://www.ncbi.nlm.nih.gov/pubmed/35294883
http://dx.doi.org/10.1016/j.celrep.2022.110514

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