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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants of foldability in the endoplasmic reticulum (ER) of...

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Detalles Bibliográficos
Autores principales:	Dhayalan, Balamurugan, Glidden, Michael D., Zaykov, Alexander N., Chen, Yen-Shan, Yang, Yanwu, Phillips, Nelson B., Ismail-Beigi, Faramarz, Jarosinski, Mark A., DiMarchi, Richard D., Weiss, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922534/ https://www.ncbi.nlm.nih.gov/pubmed/35299972 http://dx.doi.org/10.3389/fendo.2022.821069

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