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A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
BACKGROUND: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic me...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922758/ https://www.ncbi.nlm.nih.gov/pubmed/35321289 http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067 |
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author | Rocha, Mackson Martins Dariva, Isabela Zornoff, Gabriela Comelli De Laurentis, Giovanna Sanches Mendes, Giulia Carli Santana, Maycon Giovani de Miguel, Guilherme Chohfi Ferreira, Rui Seabra Sciani, Juliana Mozer Priolli, Denise Gonçalves |
author_facet | Rocha, Mackson Martins Dariva, Isabela Zornoff, Gabriela Comelli De Laurentis, Giovanna Sanches Mendes, Giulia Carli Santana, Maycon Giovani de Miguel, Guilherme Chohfi Ferreira, Rui Seabra Sciani, Juliana Mozer Priolli, Denise Gonçalves |
author_sort | Rocha, Mackson Martins |
collection | PubMed |
description | BACKGROUND: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. METHODS: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. RESULTS: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. CONCLUSION: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis. |
format | Online Article Text |
id | pubmed-8922758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
record_format | MEDLINE/PubMed |
spelling | pubmed-89227582022-03-22 A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin Rocha, Mackson Martins Dariva, Isabela Zornoff, Gabriela Comelli De Laurentis, Giovanna Sanches Mendes, Giulia Carli Santana, Maycon Giovani de Miguel, Guilherme Chohfi Ferreira, Rui Seabra Sciani, Juliana Mozer Priolli, Denise Gonçalves J Venom Anim Toxins Incl Trop Dis Research BACKGROUND: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. METHODS: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. RESULTS: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. CONCLUSION: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis. Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2022-03-14 /pmc/articles/PMC8922758/ /pubmed/35321289 http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067 Text en https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Rocha, Mackson Martins Dariva, Isabela Zornoff, Gabriela Comelli De Laurentis, Giovanna Sanches Mendes, Giulia Carli Santana, Maycon Giovani de Miguel, Guilherme Chohfi Ferreira, Rui Seabra Sciani, Juliana Mozer Priolli, Denise Gonçalves A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title | A new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
title_full | A new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
title_fullStr | A new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
title_full_unstemmed | A new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
title_short | A new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
title_sort | new therapeutic approach for bone metastasis in colorectal cancer:
intratumoral melittin |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922758/ https://www.ncbi.nlm.nih.gov/pubmed/35321289 http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0067 |
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