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Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction
BACKGROUND: Many studies have shown malnutrition and inadequate caloric consumption have adverse acute effects on cardiovascular structure and function. METHODS: To determine the adverse long term cardiovascular effects, we studied cardiac morphology and function in female (F) and male (M) severe fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922835/ https://www.ncbi.nlm.nih.gov/pubmed/35292078 http://dx.doi.org/10.1186/s13293-022-00419-1 |
Sumario: | BACKGROUND: Many studies have shown malnutrition and inadequate caloric consumption have adverse acute effects on cardiovascular structure and function. METHODS: To determine the adverse long term cardiovascular effects, we studied cardiac morphology and function in female (F) and male (M) severe food restricted rats 3 months after refeeding (sFR-Refed). RESULTS: Two weeks of a normal chow diet in which calories were reduced by 60% decreased body weight (BW) by approximately 15% in both sexes. Within 2 weeks of refeeding, no differences in BW were detected between CT and sFR-Refed groups. However, male rats gained almost 3 times more BW than the females over the 3-month refeeding period. Sex differences were also observed in cardiac pathology. Hearts from F-sFR-Refed rats exhibited more atrophy and less hypertrophy, while M-sFR-Refed rats predominantly exhibited hypertrophic remodeling. While there were no differences in the frequency of ventricular arrhythmias induced by ischemia/reperfusion (I/R) in the isolated heart between M-CT and M-sFR-Refed rats, I/R induced twice as many arrhythmias in the F-sFR-Refed rats compared to F-CT. CONCLUSIONS: These findings indicate the female heart is more susceptible to the long term adverse cardiovascular effects of sFR months after refeeding. Thus, this study provides a rationale for studying sex differences in cardiovascular risk in individuals who experience sFR for voluntary (e.g., very low-calorie dieting) or involuntary (e.g., poverty) reasons earlier in life. |
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