Engineered extracellular vesicles: potentials in cancer combination therapy

Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with ot...

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Detalles Bibliográficos
Autores principales: Chen, Jiangbin, Tan, Qi, Yang, Zimo, Jin, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922858/
https://www.ncbi.nlm.nih.gov/pubmed/35292030
http://dx.doi.org/10.1186/s12951-022-01330-y
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author Chen, Jiangbin
Tan, Qi
Yang, Zimo
Jin, Yang
author_facet Chen, Jiangbin
Tan, Qi
Yang, Zimo
Jin, Yang
author_sort Chen, Jiangbin
collection PubMed
description Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with other nanocarriers. With the development of this field, multiple ingenious modification methods have been developed to obtain engineered EVs with desired performance. Application of engineered EVs in cancer therapy has gradually shifted from monotherapy to combinational therapy to fight against heterogeneous cancer cells and complex tumor microenvironment. In addition, the strong plasticity and load capacity of engineered EV make it potential to achieve various combinations of cancer treatment methods. In this review, we summarize the existing schemes of cancer combination therapy realized by engineered EVs, highlight the mechanisms and representative examples of these schemes and provide guidance for the future application of engineered EVs to design more effective cancer combination treatment plans. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-89228582022-03-22 Engineered extracellular vesicles: potentials in cancer combination therapy Chen, Jiangbin Tan, Qi Yang, Zimo Jin, Yang J Nanobiotechnology Review Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with other nanocarriers. With the development of this field, multiple ingenious modification methods have been developed to obtain engineered EVs with desired performance. Application of engineered EVs in cancer therapy has gradually shifted from monotherapy to combinational therapy to fight against heterogeneous cancer cells and complex tumor microenvironment. In addition, the strong plasticity and load capacity of engineered EV make it potential to achieve various combinations of cancer treatment methods. In this review, we summarize the existing schemes of cancer combination therapy realized by engineered EVs, highlight the mechanisms and representative examples of these schemes and provide guidance for the future application of engineered EVs to design more effective cancer combination treatment plans. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-03-15 /pmc/articles/PMC8922858/ /pubmed/35292030 http://dx.doi.org/10.1186/s12951-022-01330-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Jiangbin
Tan, Qi
Yang, Zimo
Jin, Yang
Engineered extracellular vesicles: potentials in cancer combination therapy
title Engineered extracellular vesicles: potentials in cancer combination therapy
title_full Engineered extracellular vesicles: potentials in cancer combination therapy
title_fullStr Engineered extracellular vesicles: potentials in cancer combination therapy
title_full_unstemmed Engineered extracellular vesicles: potentials in cancer combination therapy
title_short Engineered extracellular vesicles: potentials in cancer combination therapy
title_sort engineered extracellular vesicles: potentials in cancer combination therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922858/
https://www.ncbi.nlm.nih.gov/pubmed/35292030
http://dx.doi.org/10.1186/s12951-022-01330-y
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AT jinyang engineeredextracellularvesiclespotentialsincancercombinationtherapy

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