BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model

BACKGROUND: Preclinical studies have indicated that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects and molecular mechanisms remain unclear. In this work, we examined the...

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Detalles Bibliográficos
Autores principales: Ju, Lingsha, Yang, Jiaojiao, Zhu, Tingting, Liu, Panmiao, Yang, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922900/
https://www.ncbi.nlm.nih.gov/pubmed/35291971
http://dx.doi.org/10.1186/s12888-022-03838-x

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