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LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-sp...

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Autores principales: Huang, Wanxu, Li, Hua, Yu, Qingsong, Xiao, Wei, Wang, Dan Ohtan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922926/
https://www.ncbi.nlm.nih.gov/pubmed/35292092
http://dx.doi.org/10.1186/s13046-022-02319-z
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author Huang, Wanxu
Li, Hua
Yu, Qingsong
Xiao, Wei
Wang, Dan Ohtan
author_facet Huang, Wanxu
Li, Hua
Yu, Qingsong
Xiao, Wei
Wang, Dan Ohtan
author_sort Huang, Wanxu
collection PubMed
description DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-specific DNA methylation patterns established or disturbed is a pivotal question in developmental biology and cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates DNA methylation in both physiological and pathological conditions. In this review, we provide an overview of the current understanding of lncRNA-mediated DNA methylation, with emphasis on the roles of this mechanism in cancer, which to the best of our knowledge, has not been systematically summarized. In addition, we also discuss the potential clinical applications of this mechanism in RNA-targeting drug development.
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spelling pubmed-89229262022-03-23 LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond Huang, Wanxu Li, Hua Yu, Qingsong Xiao, Wei Wang, Dan Ohtan J Exp Clin Cancer Res Review DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-specific DNA methylation patterns established or disturbed is a pivotal question in developmental biology and cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates DNA methylation in both physiological and pathological conditions. In this review, we provide an overview of the current understanding of lncRNA-mediated DNA methylation, with emphasis on the roles of this mechanism in cancer, which to the best of our knowledge, has not been systematically summarized. In addition, we also discuss the potential clinical applications of this mechanism in RNA-targeting drug development. BioMed Central 2022-03-15 /pmc/articles/PMC8922926/ /pubmed/35292092 http://dx.doi.org/10.1186/s13046-022-02319-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Wanxu
Li, Hua
Yu, Qingsong
Xiao, Wei
Wang, Dan Ohtan
LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title_full LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title_fullStr LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title_full_unstemmed LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title_short LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
title_sort lncrna-mediated dna methylation: an emerging mechanism in cancer and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922926/
https://www.ncbi.nlm.nih.gov/pubmed/35292092
http://dx.doi.org/10.1186/s13046-022-02319-z
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