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CYP1B1-catalyzed 4-OHE2 promotes the castration resistance of prostate cancer stem cells by estrogen receptor α-mediated IL6 activation

BACKGROUND: Resistance to androgen deprivation therapy remains a major challenge for the clinical treatment of patients with castration-resistant prostate cancer (CRPC). CYP1B1, a critical enzyme that catalyzes the conversion of estradiol to 4-Hydroxy-17β-estradiol (4-OHE2), has been reported to pro...

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Detalles Bibliográficos
Autores principales:	Lin, Qimei, Cao, Jiasong, Du, Xiaoling, Yang, Kuo, Yang, Xu, Liang, Zhixian, Shi, Jiandang, Zhang, Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922936/ https://www.ncbi.nlm.nih.gov/pubmed/35292057 http://dx.doi.org/10.1186/s12964-021-00807-x

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