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Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer

BACKGROUND: BRCA1‐associated RING Domain 1 (BARD1) is an important gene related to breast cancer development. However, the role of BARD1 mutations in breast cancer remains inconclusive. This study is to investigate the relationship between exon mutations of BARD1 gene and the risk of early‐onset bre...

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Autores principales: Wu, Jun, Aini, Alibiati, Ma, Binlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922950/
https://www.ncbi.nlm.nih.gov/pubmed/35084806
http://dx.doi.org/10.1002/mgg3.1847
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author Wu, Jun
Aini, Alibiati
Ma, Binlin
author_facet Wu, Jun
Aini, Alibiati
Ma, Binlin
author_sort Wu, Jun
collection PubMed
description BACKGROUND: BRCA1‐associated RING Domain 1 (BARD1) is an important gene related to breast cancer development. However, the role of BARD1 mutations in breast cancer remains inconclusive. This study is to investigate the relationship between exon mutations of BARD1 gene and the risk of early‐onset breast cancer. METHODS: Totally, 60 cases of early‐onset breast cancer patients (age 30–40 years) and 240 healthy women (age 30–40 years) were enrolled. Exon mutations of BARD1 were detected and analyzed by direct sequencing and SNaPshot. RESULTS: The risk of breast cancer was increased by 3.475 times in carriers with deletion mutation at rs28997575 site of BARD1 (aOR(1) = 3.475, 95%CI = 1.302–9.276) (p = 0.013). The risk of breast cancer in carriers with GC genotype at rs2229571 site of BARD1 was reduced by 72.6% (aOR(1) = 0.274, 95%CI = 0.134–0.562) (p = 0.001), and that in carriers with CC genotype was reduced by 82.8% (aOR(1) = 0.172, 95%CI = 0.076–0.392) (p = 0.001). After stratification with family history, the difference of rs2229571 site mutation genotype was statistically significant (OR = −2.169, 95%CI = 0.016–0.828, p = 0.032). Additionally, the frequency distribution of breast cancer family history in the case group (15%) was significantly more than that in the control group (6.7%) (p = 0.037). CONCLUSION: The deletion mutation at rs28997575 locus of the BARD1 gene can significantly increase the risk of breast cancer. The mutation genotype of rs2229571 locus can significantly reduce the risk of breast cancer. Family history is associated with BARD1 gene polymorphism. A family history of breast cancer may be a risk factor for breast cancer.
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spelling pubmed-89229502022-03-21 Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer Wu, Jun Aini, Alibiati Ma, Binlin Mol Genet Genomic Med Original Articles BACKGROUND: BRCA1‐associated RING Domain 1 (BARD1) is an important gene related to breast cancer development. However, the role of BARD1 mutations in breast cancer remains inconclusive. This study is to investigate the relationship between exon mutations of BARD1 gene and the risk of early‐onset breast cancer. METHODS: Totally, 60 cases of early‐onset breast cancer patients (age 30–40 years) and 240 healthy women (age 30–40 years) were enrolled. Exon mutations of BARD1 were detected and analyzed by direct sequencing and SNaPshot. RESULTS: The risk of breast cancer was increased by 3.475 times in carriers with deletion mutation at rs28997575 site of BARD1 (aOR(1) = 3.475, 95%CI = 1.302–9.276) (p = 0.013). The risk of breast cancer in carriers with GC genotype at rs2229571 site of BARD1 was reduced by 72.6% (aOR(1) = 0.274, 95%CI = 0.134–0.562) (p = 0.001), and that in carriers with CC genotype was reduced by 82.8% (aOR(1) = 0.172, 95%CI = 0.076–0.392) (p = 0.001). After stratification with family history, the difference of rs2229571 site mutation genotype was statistically significant (OR = −2.169, 95%CI = 0.016–0.828, p = 0.032). Additionally, the frequency distribution of breast cancer family history in the case group (15%) was significantly more than that in the control group (6.7%) (p = 0.037). CONCLUSION: The deletion mutation at rs28997575 locus of the BARD1 gene can significantly increase the risk of breast cancer. The mutation genotype of rs2229571 locus can significantly reduce the risk of breast cancer. Family history is associated with BARD1 gene polymorphism. A family history of breast cancer may be a risk factor for breast cancer. John Wiley and Sons Inc. 2022-01-27 /pmc/articles/PMC8922950/ /pubmed/35084806 http://dx.doi.org/10.1002/mgg3.1847 Text en © 2022 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Wu, Jun
Aini, Alibiati
Ma, Binlin
Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title_full Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title_fullStr Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title_full_unstemmed Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title_short Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer
title_sort mutations in exon region of brca1‐related ring domain 1 gene and risk of breast cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922950/
https://www.ncbi.nlm.nih.gov/pubmed/35084806
http://dx.doi.org/10.1002/mgg3.1847
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