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Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets

Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance....

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Autores principales: Lin, Chenglong, Liang, Shunshun, Peng, Yusi, Long, Li, Li, Yanyan, Huang, Zhengren, Long, Nguyen Viet, Luo, Xiaoying, Liu, Jianjun, Li, Zhiyuan, Yang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922987/
https://www.ncbi.nlm.nih.gov/pubmed/35290533
http://dx.doi.org/10.1007/s40820-022-00803-x
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author Lin, Chenglong
Liang, Shunshun
Peng, Yusi
Long, Li
Li, Yanyan
Huang, Zhengren
Long, Nguyen Viet
Luo, Xiaoying
Liu, Jianjun
Li, Zhiyuan
Yang, Yong
author_facet Lin, Chenglong
Liang, Shunshun
Peng, Yusi
Long, Li
Li, Yanyan
Huang, Zhengren
Long, Nguyen Viet
Luo, Xiaoying
Liu, Jianjun
Li, Zhiyuan
Yang, Yong
author_sort Lin, Chenglong
collection PubMed
description Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule. The recognition of different tumor exosomes can be realized combining the method of machine learning. ABSTRACT: Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10(–20) mol L(−1) for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00803-x.
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spelling pubmed-89229872022-03-15 Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets Lin, Chenglong Liang, Shunshun Peng, Yusi Long, Li Li, Yanyan Huang, Zhengren Long, Nguyen Viet Luo, Xiaoying Liu, Jianjun Li, Zhiyuan Yang, Yong Nanomicro Lett Article Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule. The recognition of different tumor exosomes can be realized combining the method of machine learning. ABSTRACT: Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10(–20) mol L(−1) for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00803-x. Springer Nature Singapore 2022-03-15 /pmc/articles/PMC8922987/ /pubmed/35290533 http://dx.doi.org/10.1007/s40820-022-00803-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lin, Chenglong
Liang, Shunshun
Peng, Yusi
Long, Li
Li, Yanyan
Huang, Zhengren
Long, Nguyen Viet
Luo, Xiaoying
Liu, Jianjun
Li, Zhiyuan
Yang, Yong
Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title_full Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title_fullStr Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title_full_unstemmed Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title_short Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
title_sort visualized sers imaging of single molecule by ag/black phosphorus nanosheets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922987/
https://www.ncbi.nlm.nih.gov/pubmed/35290533
http://dx.doi.org/10.1007/s40820-022-00803-x
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