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Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922987/ https://www.ncbi.nlm.nih.gov/pubmed/35290533 http://dx.doi.org/10.1007/s40820-022-00803-x |
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author | Lin, Chenglong Liang, Shunshun Peng, Yusi Long, Li Li, Yanyan Huang, Zhengren Long, Nguyen Viet Luo, Xiaoying Liu, Jianjun Li, Zhiyuan Yang, Yong |
author_facet | Lin, Chenglong Liang, Shunshun Peng, Yusi Long, Li Li, Yanyan Huang, Zhengren Long, Nguyen Viet Luo, Xiaoying Liu, Jianjun Li, Zhiyuan Yang, Yong |
author_sort | Lin, Chenglong |
collection | PubMed |
description | Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule. The recognition of different tumor exosomes can be realized combining the method of machine learning. ABSTRACT: Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10(–20) mol L(−1) for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00803-x. |
format | Online Article Text |
id | pubmed-8922987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-89229872022-03-15 Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets Lin, Chenglong Liang, Shunshun Peng, Yusi Long, Li Li, Yanyan Huang, Zhengren Long, Nguyen Viet Luo, Xiaoying Liu, Jianjun Li, Zhiyuan Yang, Yong Nanomicro Lett Article Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule. The recognition of different tumor exosomes can be realized combining the method of machine learning. ABSTRACT: Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10(–20) mol L(−1) for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-022-00803-x. Springer Nature Singapore 2022-03-15 /pmc/articles/PMC8922987/ /pubmed/35290533 http://dx.doi.org/10.1007/s40820-022-00803-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lin, Chenglong Liang, Shunshun Peng, Yusi Long, Li Li, Yanyan Huang, Zhengren Long, Nguyen Viet Luo, Xiaoying Liu, Jianjun Li, Zhiyuan Yang, Yong Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title | Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title_full | Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title_fullStr | Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title_full_unstemmed | Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title_short | Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets |
title_sort | visualized sers imaging of single molecule by ag/black phosphorus nanosheets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922987/ https://www.ncbi.nlm.nih.gov/pubmed/35290533 http://dx.doi.org/10.1007/s40820-022-00803-x |
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