An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect

BACKGROUND: Diffuse Midline Glioma, H3K27M-mutant (DMG) is a rare, highly aggressive pediatric tumor affecting the brainstem, and is one of the deadliest cancers. Currently available treatment options such as chemotherapy and radiotherapy do only modestly prolong survival. In this pathology, H3K27 m...

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Detalles Bibliográficos
Autores principales: Rahal, Farah, Capdevielle, Caroline, Rousseau, Benoit, Izotte, Julien, Dupuy, Jean-William, Cappellen, David, Chotard, Guillaume, Ménard, Mélissa, Charpentier, Justine, Jecko, Vincent, Caumont, Charline, Gimbert, Edouard, Grosset, Christophe F, Hagedorn, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923007/
https://www.ncbi.nlm.nih.gov/pubmed/35300150
http://dx.doi.org/10.1093/noajnl/vdac018

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