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Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren

Although there are many examples in the experimental literature of an environmental exposure in one generation impacting the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALS...

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Autores principales: Golding, Jean, Pembrey, Marcus E, Gregory, Steven, Suderman, Matthew, Iles-Caven, Yasmin, Northstone, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923060/
https://www.ncbi.nlm.nih.gov/pubmed/35299985
http://dx.doi.org/10.1093/eep/dvac003
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author Golding, Jean
Pembrey, Marcus E
Gregory, Steven
Suderman, Matthew
Iles-Caven, Yasmin
Northstone, Kate
author_facet Golding, Jean
Pembrey, Marcus E
Gregory, Steven
Suderman, Matthew
Iles-Caven, Yasmin
Northstone, Kate
author_sort Golding, Jean
collection PubMed
description Although there are many examples in the experimental literature of an environmental exposure in one generation impacting the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALSPAC) has, however, been able to determine whether there are associations between grandparental exposures and their grandchildren’s development. Several of our studies, including sensitivity to loud noise, have shown associations between a grandmother smoking in pregnancy and the phenotype of the grandchild. These results were mostly specific to the sex of the grandchild and to whether the prenatal (i.e. during pregnancy) smoking occurred in the maternal or paternal grandmother. Here, we have used ancestral data on prenatal smoking among the grandmothers of the ALSPAC index children to examine possible effects on the grandchild’s ability to detect the bitter taste of PROP (6 n-propylthiouracil), distinguishing between the 10% deemed ‘extreme tasters’, and the rest of the population (total N = 4656 children). We showed that grandchildren whose paternal (but not maternal) grandmothers had smoked in pregnancy were more likely than those of non-smoking grandmothers to be extreme tasters [odds ratio (OR) 1.28; 95% confidence interval (CI) 1.03, 1.59] and that this was more likely in granddaughters (OR 1.42; 95% CI 1.03, 1.95) than grandsons (OR 1.18; 95% CI 0.88, 1.60). This pattern of association between paternal foetal exposure and the granddaughter’s development has been found with several other outcomes, suggesting that investigations should be undertaken to investigate possible mechanisms.
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spelling pubmed-89230602022-03-16 Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren Golding, Jean Pembrey, Marcus E Gregory, Steven Suderman, Matthew Iles-Caven, Yasmin Northstone, Kate Environ Epigenet Research Article Although there are many examples in the experimental literature of an environmental exposure in one generation impacting the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALSPAC) has, however, been able to determine whether there are associations between grandparental exposures and their grandchildren’s development. Several of our studies, including sensitivity to loud noise, have shown associations between a grandmother smoking in pregnancy and the phenotype of the grandchild. These results were mostly specific to the sex of the grandchild and to whether the prenatal (i.e. during pregnancy) smoking occurred in the maternal or paternal grandmother. Here, we have used ancestral data on prenatal smoking among the grandmothers of the ALSPAC index children to examine possible effects on the grandchild’s ability to detect the bitter taste of PROP (6 n-propylthiouracil), distinguishing between the 10% deemed ‘extreme tasters’, and the rest of the population (total N = 4656 children). We showed that grandchildren whose paternal (but not maternal) grandmothers had smoked in pregnancy were more likely than those of non-smoking grandmothers to be extreme tasters [odds ratio (OR) 1.28; 95% confidence interval (CI) 1.03, 1.59] and that this was more likely in granddaughters (OR 1.42; 95% CI 1.03, 1.95) than grandsons (OR 1.18; 95% CI 0.88, 1.60). This pattern of association between paternal foetal exposure and the granddaughter’s development has been found with several other outcomes, suggesting that investigations should be undertaken to investigate possible mechanisms. Oxford University Press 2022-02-16 /pmc/articles/PMC8923060/ /pubmed/35299985 http://dx.doi.org/10.1093/eep/dvac003 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Golding, Jean
Pembrey, Marcus E
Gregory, Steven
Suderman, Matthew
Iles-Caven, Yasmin
Northstone, Kate
Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title_full Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title_fullStr Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title_full_unstemmed Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title_short Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
title_sort paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923060/
https://www.ncbi.nlm.nih.gov/pubmed/35299985
http://dx.doi.org/10.1093/eep/dvac003
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