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The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Nature Singapore
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923085/ https://www.ncbi.nlm.nih.gov/pubmed/35292745 http://dx.doi.org/10.1038/s41422-022-00640-y |
| _version_ | 1784669621150810112 |
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| author | Sacco, Michael Dominic Hu, Yanmei Gongora, Maura Verenice Meilleur, Flora Kemp, Michael Trent Zhang, Xiujun Wang, Jun Chen, Yu |
| author_facet | Sacco, Michael Dominic Hu, Yanmei Gongora, Maura Verenice Meilleur, Flora Kemp, Michael Trent Zhang, Xiujun Wang, Jun Chen, Yu |
| author_sort | Sacco, Michael Dominic |
| collection | PubMed |
| description | |
| format | Online Article Text |
| id | pubmed-8923085 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Springer Nature Singapore |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89230852022-03-15 The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition Sacco, Michael Dominic Hu, Yanmei Gongora, Maura Verenice Meilleur, Flora Kemp, Michael Trent Zhang, Xiujun Wang, Jun Chen, Yu Cell Res Letter to the Editor Springer Nature Singapore 2022-03-15 2022-05 /pmc/articles/PMC8923085/ /pubmed/35292745 http://dx.doi.org/10.1038/s41422-022-00640-y Text en © The Author(s) under exclusive licence to Center for Excellence in Molecular Cell Science, CAS 2022 |
| spellingShingle | Letter to the Editor Sacco, Michael Dominic Hu, Yanmei Gongora, Maura Verenice Meilleur, Flora Kemp, Michael Trent Zhang, Xiujun Wang, Jun Chen, Yu The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title_full | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title_fullStr | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title_full_unstemmed | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title_short | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| title_sort | p132h mutation in the main protease of omicron sars-cov-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition |
| topic | Letter to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923085/ https://www.ncbi.nlm.nih.gov/pubmed/35292745 http://dx.doi.org/10.1038/s41422-022-00640-y |
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