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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against coronaviruses that cause severe disease, for anticipating novel pandemic-causing viruses, and to respond more effectively to SARS-CoV-2 variants. The emergence of the Omicron variant of SAR...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923106/ https://www.ncbi.nlm.nih.gov/pubmed/35291291 http://dx.doi.org/10.1101/2022.03.04.479488 |
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author | Zhou, Panpan Song, Ge He, Wan-ting Beutler, Nathan Tse, Longping V. Martinez, David R. Schäfer, Alexandra Anzanello, Fabio Yong, Peter Peng, Linghang Dueker, Katharina Musharrafieh, Rami Callaghan, Sean Capozzola, Tazio Yuan, Meng Liu, Hejun Limbo, Oliver Parren, Mara Garcia, Elijah Rawlings, Stephen A. Smith, Davey M. Nemazee, David Jardine, Joseph G. Wilson, Ian A. Safonova, Yana Rogers, Thomas F. Baric, Ralph S. Gralinski, Lisa E. Burton, Dennis R. Andrabi, Raiees |
author_facet | Zhou, Panpan Song, Ge He, Wan-ting Beutler, Nathan Tse, Longping V. Martinez, David R. Schäfer, Alexandra Anzanello, Fabio Yong, Peter Peng, Linghang Dueker, Katharina Musharrafieh, Rami Callaghan, Sean Capozzola, Tazio Yuan, Meng Liu, Hejun Limbo, Oliver Parren, Mara Garcia, Elijah Rawlings, Stephen A. Smith, Davey M. Nemazee, David Jardine, Joseph G. Wilson, Ian A. Safonova, Yana Rogers, Thomas F. Baric, Ralph S. Gralinski, Lisa E. Burton, Dennis R. Andrabi, Raiees |
author_sort | Zhou, Panpan |
collection | PubMed |
description | Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against coronaviruses that cause severe disease, for anticipating novel pandemic-causing viruses, and to respond more effectively to SARS-CoV-2 variants. The emergence of the Omicron variant of SARS-CoV-2 has illustrated the limitations of solely targeting the receptor binding domain (RBD) of the envelope Spike (S)-protein. Here, we isolated a large panel of broadly neutralizing antibodies (bnAbs) from SARS-CoV-2 recovered-vaccinated donors that target a conserved S2 region in the fusion machinery on betacoronavirus spikes. Select bnAbs show broad in vivo protection against all three pathogenic betacoronaviruses, SARS-CoV-1, SARS-CoV-2 and MERS-CoV, that have spilled over into humans in the past 20 years to cause severe disease. The bnAbs provide new opportunities for antibody-based interventions and key insights for developing pan-betacoronavirus vaccines. |
format | Online Article Text |
id | pubmed-8923106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-89231062022-03-16 Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease Zhou, Panpan Song, Ge He, Wan-ting Beutler, Nathan Tse, Longping V. Martinez, David R. Schäfer, Alexandra Anzanello, Fabio Yong, Peter Peng, Linghang Dueker, Katharina Musharrafieh, Rami Callaghan, Sean Capozzola, Tazio Yuan, Meng Liu, Hejun Limbo, Oliver Parren, Mara Garcia, Elijah Rawlings, Stephen A. Smith, Davey M. Nemazee, David Jardine, Joseph G. Wilson, Ian A. Safonova, Yana Rogers, Thomas F. Baric, Ralph S. Gralinski, Lisa E. Burton, Dennis R. Andrabi, Raiees bioRxiv Article Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against coronaviruses that cause severe disease, for anticipating novel pandemic-causing viruses, and to respond more effectively to SARS-CoV-2 variants. The emergence of the Omicron variant of SARS-CoV-2 has illustrated the limitations of solely targeting the receptor binding domain (RBD) of the envelope Spike (S)-protein. Here, we isolated a large panel of broadly neutralizing antibodies (bnAbs) from SARS-CoV-2 recovered-vaccinated donors that target a conserved S2 region in the fusion machinery on betacoronavirus spikes. Select bnAbs show broad in vivo protection against all three pathogenic betacoronaviruses, SARS-CoV-1, SARS-CoV-2 and MERS-CoV, that have spilled over into humans in the past 20 years to cause severe disease. The bnAbs provide new opportunities for antibody-based interventions and key insights for developing pan-betacoronavirus vaccines. Cold Spring Harbor Laboratory 2022-03-07 /pmc/articles/PMC8923106/ /pubmed/35291291 http://dx.doi.org/10.1101/2022.03.04.479488 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Zhou, Panpan Song, Ge He, Wan-ting Beutler, Nathan Tse, Longping V. Martinez, David R. Schäfer, Alexandra Anzanello, Fabio Yong, Peter Peng, Linghang Dueker, Katharina Musharrafieh, Rami Callaghan, Sean Capozzola, Tazio Yuan, Meng Liu, Hejun Limbo, Oliver Parren, Mara Garcia, Elijah Rawlings, Stephen A. Smith, Davey M. Nemazee, David Jardine, Joseph G. Wilson, Ian A. Safonova, Yana Rogers, Thomas F. Baric, Ralph S. Gralinski, Lisa E. Burton, Dennis R. Andrabi, Raiees Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title | Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title_full | Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title_fullStr | Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title_full_unstemmed | Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title_short | Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease |
title_sort | broadly neutralizing anti-s2 antibodies protect against all three human betacoronaviruses that cause severe disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923106/ https://www.ncbi.nlm.nih.gov/pubmed/35291291 http://dx.doi.org/10.1101/2022.03.04.479488 |
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