Cargando…

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication

Mostrar otras versiones (1)

New therapeutic targets are a valuable resource in the struggle to reduce the morbidity and mortality associated with the COVID-19 pandemic, caused by the SARS-CoV-2 virus. Genome-wide association studies (GWAS) have identified risk loci, but some loci are associated with co-morbidities and are not...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moll, Tobias, Odon, Valerie, Harvey, Calum, Collins, Mark O, Peden, Andrew, Franklin, John, Graves, Emily, Marshall, Jack N.G., Souza, Cleide dos Santos, Zhang, Sai, Azzouz, Mimoun, Gordon, David, Krogan, Nevan, Ferraiuolo, Laura, Snyder, Michael P, Shaw, Pamela J, Rehwinkel, Jan, Cooper-Knock, Johnathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923113/ https://www.ncbi.nlm.nih.gov/pubmed/35291294 http://dx.doi.org/10.1101/2022.03.06.483172

Ejemplares similares

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication
por: Moll, Tobias, et al.
Publicado: (2022)

Integrated Bioinformatic Investigation of EXOSCs in Hepatocellular Carcinoma Followed by the Preliminary Validation of EXOSC5 in Cell Proliferation
por: Zhang, Yujing, et al.
Publicado: (2022)

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes
por: Julian, Thomas H, et al.
Publicado: (2021)

Advances in the Genetic Classification of ALS
por: Cooper-Knock, Johnathan, et al.
Publicado: (2021)

Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration
por: Moll, Tobias, et al.
Publicado: (2020)

Towards 3D Bioprinted Spinal Cord Organoids
por: Han, Yilin, et al.
Publicado: (2022)

Membrane lipid raft homeostasis is directly linked to neurodegeneration
por: Moll, Tobias, et al.
Publicado: (2021)

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis
por: Knight, John R.P., et al.
Publicado: (2016)

Identification of single nucleotide variants in the Moroccan population by whole-genome sequencing
por: Crooks, Lucy, et al.
Publicado: (2020)

A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex
por: Sterrett, Maria C., et al.
Publicado: (2021)

Atypical hemolytic uremic syndrome induced by SARS-CoV2 infection in infants with EXOSC3 mutation
por: Van Quekelberghe, Chantal, et al.
Publicado: (2022)

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
por: Gatto, Noemi, et al.
Publicado: (2020)

EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations
por: Eggens, Veerle RC, et al.
Publicado: (2014)

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy
por: Burns, David T., et al.
Publicado: (2018)

EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells
por: Yoshino, Seiko, et al.
Publicado: (2020)

Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control
por: Davidson, Lee, et al.
Publicado: (2019)

EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis
por: Jamin, Soazik P., et al.
Publicado: (2017)

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
por: Domingo-Prim, Judit, et al.
Publicado: (2019)

RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival
por: Taniue, Kenzui, et al.
Publicado: (2022)

EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways
por: Chen, Xiangliu, et al.
Publicado: (2022)

The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype
por: Cooper-Knock, Johnathan, et al.
Publicado: (2014)

Physical activity as an exogenous risk factor for amyotrophic lateral sclerosis: a review of the evidence
por: Chapman, Laura, et al.
Publicado: (2023)

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration
por: Wan, Jijun, et al.
Publicado: (2012)

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
por: Boczonadi, Veronika, et al.
Publicado: (2014)

Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice
por: Demini, Leïla, et al.
Publicado: (2023)

EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a comprehensive bioinformatics analysis and experiment verification
por: Meng, Zhi-Yong, et al.
Publicado: (2023)

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten
por: Stopford, Matthew J., et al.
Publicado: (2017)

Differential network biology
por: Ideker, Trey, et al.
Publicado: (2012)

Mapping genetic interactions in cancer: a road to rational combination therapies
por: Tutuncuoglu, Beril, et al.
Publicado: (2019)

EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways
por: Pan, Hongda, et al.
Publicado: (2019)

A Biallelic Variant of the RNA Exosome Gene EXOSC4 Causes Translational Defects Associated with a Neurodevelopmental Disorder
por: Fasken, Milo B., et al.
Publicado: (2023)

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
por: Castelli, Lydia M., et al.
Publicado: (2021)

Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis
por: Boddy, Sarah, et al.
Publicado: (2022)

The Spectrum of C9orf72-mediated Neurodegeneration and Amyotrophic Lateral Sclerosis
por: Cooper-Knock, Johnathan, et al.
Publicado: (2015)

Signals and systems
por: Krogan, Nevan J, et al.
Publicado: (2006)

The next frontier of systems biology: higher-order and interspecies interactions
por: Fischbach, Michael A, et al.
Publicado: (2010)

Creating collaboration by breaking down scientific barriers
por: Fabius, Jacqueline M., et al.
Publicado: (2021)

Lessons learned for pandemic preparedness: A collaborative network is imperative
por: Fabius, Jacqueline M., et al.
Publicado: (2023)

AAV9‐mediated AIRE gene delivery clears circulating antibodies and tissue T‐cell infiltration in a mouse model of autoimmune polyglandular syndrome type‐1
por: Almaghrabi, Sarah, et al.
Publicado: (2020)

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis
por: Kirby, Janine, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ak5aa6q4dvvkg6r1lc4am8i5bd