High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development

Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (SAM; 1.62Å), S-adenosylhomocysteine (SAH; 1.55Å) and Sinefungin (SFG; 1.41Å). We identify f...

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Detalles Bibliográficos
Autores principales: Aggarwal, Aneel, Kottur, Jithesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923114/
https://www.ncbi.nlm.nih.gov/pubmed/35291302
http://dx.doi.org/10.21203/rs.3.rs-1370473/v1
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author Aggarwal, Aneel
Kottur, Jithesh
author_facet Aggarwal, Aneel
Kottur, Jithesh
author_sort Aggarwal, Aneel
collection PubMed
description Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (SAM; 1.62Å), S-adenosylhomocysteine (SAH; 1.55Å) and Sinefungin (SFG; 1.41Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.
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spelling pubmed-89231142022-03-16 High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development Aggarwal, Aneel Kottur, Jithesh Res Sq Article Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (SAM; 1.62Å), S-adenosylhomocysteine (SAH; 1.55Å) and Sinefungin (SFG; 1.41Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses. American Journal Experts 2022-03-08 /pmc/articles/PMC8923114/ /pubmed/35291302 http://dx.doi.org/10.21203/rs.3.rs-1370473/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Aggarwal, Aneel
Kottur, Jithesh
High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title_full High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title_fullStr High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title_full_unstemmed High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title_short High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
title_sort high resolution structures of the sars-cov-2 n7-methyltransferase inform therapeutic development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923114/
https://www.ncbi.nlm.nih.gov/pubmed/35291302
http://dx.doi.org/10.21203/rs.3.rs-1370473/v1
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