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The Role of Bacterial Membrane Vesicles in Human Health and Disease
Bacterial membrane vesicles (MVs) are nanoparticles derived from the membrane components of bacteria that transport microbial derived substances. MVs are ubiquitous across a variety of terrestrial and marine environments and vary widely in their composition and function. Membrane vesicle functional...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923303/ https://www.ncbi.nlm.nih.gov/pubmed/35300484 http://dx.doi.org/10.3389/fmicb.2022.828704 |
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author | Villageliu, Daniel N. Samuelson, Derrick R. |
author_facet | Villageliu, Daniel N. Samuelson, Derrick R. |
author_sort | Villageliu, Daniel N. |
collection | PubMed |
description | Bacterial membrane vesicles (MVs) are nanoparticles derived from the membrane components of bacteria that transport microbial derived substances. MVs are ubiquitous across a variety of terrestrial and marine environments and vary widely in their composition and function. Membrane vesicle functional diversity is staggering: MVs facilitate intercellular communication by delivering quorum signals, genetic information, and small molecules active against a variety of receptors. MVs can deliver destructive virulence factors, alter the composition of the microbiota, take part in the formation of biofilms, assist in the uptake of nutrients, and serve as a chemical waste removal system for bacteria. MVs also facilitate host–microbe interactions including communication. Released in mass, MVs overwhelm the host immune system and injure host tissues; however, there is also evidence that vesicles may take part in processes which promote host health. This review will examine the ascribed functions of MVs within the context of human health and disease. |
format | Online Article Text |
id | pubmed-8923303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89233032022-03-16 The Role of Bacterial Membrane Vesicles in Human Health and Disease Villageliu, Daniel N. Samuelson, Derrick R. Front Microbiol Microbiology Bacterial membrane vesicles (MVs) are nanoparticles derived from the membrane components of bacteria that transport microbial derived substances. MVs are ubiquitous across a variety of terrestrial and marine environments and vary widely in their composition and function. Membrane vesicle functional diversity is staggering: MVs facilitate intercellular communication by delivering quorum signals, genetic information, and small molecules active against a variety of receptors. MVs can deliver destructive virulence factors, alter the composition of the microbiota, take part in the formation of biofilms, assist in the uptake of nutrients, and serve as a chemical waste removal system for bacteria. MVs also facilitate host–microbe interactions including communication. Released in mass, MVs overwhelm the host immune system and injure host tissues; however, there is also evidence that vesicles may take part in processes which promote host health. This review will examine the ascribed functions of MVs within the context of human health and disease. Frontiers Media S.A. 2022-03-01 /pmc/articles/PMC8923303/ /pubmed/35300484 http://dx.doi.org/10.3389/fmicb.2022.828704 Text en Copyright © 2022 Villageliu and Samuelson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Villageliu, Daniel N. Samuelson, Derrick R. The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title | The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title_full | The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title_fullStr | The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title_full_unstemmed | The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title_short | The Role of Bacterial Membrane Vesicles in Human Health and Disease |
title_sort | role of bacterial membrane vesicles in human health and disease |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923303/ https://www.ncbi.nlm.nih.gov/pubmed/35300484 http://dx.doi.org/10.3389/fmicb.2022.828704 |
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