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The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience

PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent....

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Autores principales: Jaiswal, Sanjeet Kumar, Sarathi, Vijaya, Malhotra, Gaurav, Verma, Priyanka, Hira, Priya, Badhe, Padma, Memon, Saba Samad, Barnabas, Rohit, Patil, Virendra A, Anurag, Lila, R, Shah, Nalini S, Bandgar, Tushar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923324/
https://www.ncbi.nlm.nih.gov/pubmed/35300451
http://dx.doi.org/10.4103/ijem.ijem_307_21
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author Jaiswal, Sanjeet Kumar
Sarathi, Vijaya
Malhotra, Gaurav
Verma, Priyanka
Hira, Priya
Badhe, Padma
Memon, Saba Samad
Barnabas, Rohit
Patil, Virendra A
Anurag,
Lila, R
Shah, Nalini S
Bandgar, Tushar
author_facet Jaiswal, Sanjeet Kumar
Sarathi, Vijaya
Malhotra, Gaurav
Verma, Priyanka
Hira, Priya
Badhe, Padma
Memon, Saba Samad
Barnabas, Rohit
Patil, Virendra A
Anurag,
Lila, R
Shah, Nalini S
Bandgar, Tushar
author_sort Jaiswal, Sanjeet Kumar
collection PubMed
description PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent. MATERIALS AND METHODS: In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and (68)Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of (68)Ga-DOTATATE PET/CT, (18)F fluorodeoxyglucose positron emission tomography CT ((18)F-FDG PET/CT, n = 53), (131)I-metaiodobenzylguanidine ((131)I-MIBG, n = 37), and CECT were compared, and diagnostic performance of (68)Ga-DOTATATE PET/CT in the detection of PPGL was calculated. RESULTS: (68)Ga-DOTATATE PET/CT had significantly higher lesion-wise sensitivity than (131)I-MIBG for both primary (94% vs 75%, P = 0.004) and metastatic disease (85% vs 59%, P = 0.001) and higher sensitivity than CECT for metastatic lesions (83% vs 43%, P = 0.0001). The lesion-wise sensitivity of (68)Ga-DOTATATE PET/CT was similar to (18)F-FDG PET/CT for both primary tumors (94% vs 85%, P = 0.08) and metastatic lesions (82% vs 84%, P = 0.76) in the whole cohort but tended to be inferior in the head to head comparison. CONCLUSION: (68)Ga-DOTATATE PET/CT had higher sensitivity for detection of PPGL than (131)I-MIBG (primary and metastatic) and CECT (metastatic) but similar to (18)F-FDG PET/CT (primary and metastatic).
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spelling pubmed-89233242022-03-16 The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience Jaiswal, Sanjeet Kumar Sarathi, Vijaya Malhotra, Gaurav Verma, Priyanka Hira, Priya Badhe, Padma Memon, Saba Samad Barnabas, Rohit Patil, Virendra A Anurag, Lila, R Shah, Nalini S Bandgar, Tushar Indian J Endocrinol Metab Original Article PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent. MATERIALS AND METHODS: In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and (68)Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of (68)Ga-DOTATATE PET/CT, (18)F fluorodeoxyglucose positron emission tomography CT ((18)F-FDG PET/CT, n = 53), (131)I-metaiodobenzylguanidine ((131)I-MIBG, n = 37), and CECT were compared, and diagnostic performance of (68)Ga-DOTATATE PET/CT in the detection of PPGL was calculated. RESULTS: (68)Ga-DOTATATE PET/CT had significantly higher lesion-wise sensitivity than (131)I-MIBG for both primary (94% vs 75%, P = 0.004) and metastatic disease (85% vs 59%, P = 0.001) and higher sensitivity than CECT for metastatic lesions (83% vs 43%, P = 0.0001). The lesion-wise sensitivity of (68)Ga-DOTATATE PET/CT was similar to (18)F-FDG PET/CT for both primary tumors (94% vs 85%, P = 0.08) and metastatic lesions (82% vs 84%, P = 0.76) in the whole cohort but tended to be inferior in the head to head comparison. CONCLUSION: (68)Ga-DOTATATE PET/CT had higher sensitivity for detection of PPGL than (131)I-MIBG (primary and metastatic) and CECT (metastatic) but similar to (18)F-FDG PET/CT (primary and metastatic). Wolters Kluwer - Medknow 2021 2022-01-12 /pmc/articles/PMC8923324/ /pubmed/35300451 http://dx.doi.org/10.4103/ijem.ijem_307_21 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Jaiswal, Sanjeet Kumar
Sarathi, Vijaya
Malhotra, Gaurav
Verma, Priyanka
Hira, Priya
Badhe, Padma
Memon, Saba Samad
Barnabas, Rohit
Patil, Virendra A
Anurag,
Lila, R
Shah, Nalini S
Bandgar, Tushar
The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title_full The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title_fullStr The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title_full_unstemmed The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title_short The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
title_sort utility of (68)ga-dotatate pet/ct in localizing primary/metastatic pheochromocytoma and paraganglioma: asian indian experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923324/
https://www.ncbi.nlm.nih.gov/pubmed/35300451
http://dx.doi.org/10.4103/ijem.ijem_307_21
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