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The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience
PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923324/ https://www.ncbi.nlm.nih.gov/pubmed/35300451 http://dx.doi.org/10.4103/ijem.ijem_307_21 |
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author | Jaiswal, Sanjeet Kumar Sarathi, Vijaya Malhotra, Gaurav Verma, Priyanka Hira, Priya Badhe, Padma Memon, Saba Samad Barnabas, Rohit Patil, Virendra A Anurag, Lila, R Shah, Nalini S Bandgar, Tushar |
author_facet | Jaiswal, Sanjeet Kumar Sarathi, Vijaya Malhotra, Gaurav Verma, Priyanka Hira, Priya Badhe, Padma Memon, Saba Samad Barnabas, Rohit Patil, Virendra A Anurag, Lila, R Shah, Nalini S Bandgar, Tushar |
author_sort | Jaiswal, Sanjeet Kumar |
collection | PubMed |
description | PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent. MATERIALS AND METHODS: In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and (68)Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of (68)Ga-DOTATATE PET/CT, (18)F fluorodeoxyglucose positron emission tomography CT ((18)F-FDG PET/CT, n = 53), (131)I-metaiodobenzylguanidine ((131)I-MIBG, n = 37), and CECT were compared, and diagnostic performance of (68)Ga-DOTATATE PET/CT in the detection of PPGL was calculated. RESULTS: (68)Ga-DOTATATE PET/CT had significantly higher lesion-wise sensitivity than (131)I-MIBG for both primary (94% vs 75%, P = 0.004) and metastatic disease (85% vs 59%, P = 0.001) and higher sensitivity than CECT for metastatic lesions (83% vs 43%, P = 0.0001). The lesion-wise sensitivity of (68)Ga-DOTATATE PET/CT was similar to (18)F-FDG PET/CT for both primary tumors (94% vs 85%, P = 0.08) and metastatic lesions (82% vs 84%, P = 0.76) in the whole cohort but tended to be inferior in the head to head comparison. CONCLUSION: (68)Ga-DOTATATE PET/CT had higher sensitivity for detection of PPGL than (131)I-MIBG (primary and metastatic) and CECT (metastatic) but similar to (18)F-FDG PET/CT (primary and metastatic). |
format | Online Article Text |
id | pubmed-8923324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-89233242022-03-16 The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience Jaiswal, Sanjeet Kumar Sarathi, Vijaya Malhotra, Gaurav Verma, Priyanka Hira, Priya Badhe, Padma Memon, Saba Samad Barnabas, Rohit Patil, Virendra A Anurag, Lila, R Shah, Nalini S Bandgar, Tushar Indian J Endocrinol Metab Original Article PURPOSE: Pheochromocytoma and paraganglioma (PGL), together called PPGL, are rare tumors with a limited number of studies on the diagnostic performance of (68)Ga-DOTA (0)-Tyr (3)-octreotate positron emission tomography-computed tomography ((68)Ga-DOTATATE PET/CT) from the Asian-Indian subcontinent. MATERIALS AND METHODS: In this retrospective study, PPGL suspects (n = 87) who had undergone at least contrast-enhanced computed tomography (CECT) and (68)Ga-DOTATATE PET/CT, were included. Lesion-wise, patient-wise, and region-wise sensitivities of (68)Ga-DOTATATE PET/CT, (18)F fluorodeoxyglucose positron emission tomography CT ((18)F-FDG PET/CT, n = 53), (131)I-metaiodobenzylguanidine ((131)I-MIBG, n = 37), and CECT were compared, and diagnostic performance of (68)Ga-DOTATATE PET/CT in the detection of PPGL was calculated. RESULTS: (68)Ga-DOTATATE PET/CT had significantly higher lesion-wise sensitivity than (131)I-MIBG for both primary (94% vs 75%, P = 0.004) and metastatic disease (85% vs 59%, P = 0.001) and higher sensitivity than CECT for metastatic lesions (83% vs 43%, P = 0.0001). The lesion-wise sensitivity of (68)Ga-DOTATATE PET/CT was similar to (18)F-FDG PET/CT for both primary tumors (94% vs 85%, P = 0.08) and metastatic lesions (82% vs 84%, P = 0.76) in the whole cohort but tended to be inferior in the head to head comparison. CONCLUSION: (68)Ga-DOTATATE PET/CT had higher sensitivity for detection of PPGL than (131)I-MIBG (primary and metastatic) and CECT (metastatic) but similar to (18)F-FDG PET/CT (primary and metastatic). Wolters Kluwer - Medknow 2021 2022-01-12 /pmc/articles/PMC8923324/ /pubmed/35300451 http://dx.doi.org/10.4103/ijem.ijem_307_21 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Jaiswal, Sanjeet Kumar Sarathi, Vijaya Malhotra, Gaurav Verma, Priyanka Hira, Priya Badhe, Padma Memon, Saba Samad Barnabas, Rohit Patil, Virendra A Anurag, Lila, R Shah, Nalini S Bandgar, Tushar The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title | The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title_full | The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title_fullStr | The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title_full_unstemmed | The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title_short | The Utility of (68)Ga-DOTATATE PET/CT in Localizing Primary/Metastatic Pheochromocytoma and Paraganglioma: Asian Indian Experience |
title_sort | utility of (68)ga-dotatate pet/ct in localizing primary/metastatic pheochromocytoma and paraganglioma: asian indian experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923324/ https://www.ncbi.nlm.nih.gov/pubmed/35300451 http://dx.doi.org/10.4103/ijem.ijem_307_21 |
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