Advances in purification of SARS-CoV-2 spike ectodomain protein using high-throughput screening and non-affinity methods

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The spike (S) glycoprotein of the pandemic virus, SARS-CoV-2, is a critically important target of vaccine design and therapeutic development. A high-yield, scalable, cGMP-compliant downstream process for the stabilized, soluble, native-like S protein ectodomain is necessary to meet the extensive mat...

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Detalles Bibliográficos
Autores principales: Cibelli, Nicole, Arias, Gabriel, Figur, McKenzie, Khayat, Shireen S., Leach, Kristin, Loukinov, Ivan, Shadrick, William, Chuenchor, Watchalee, Tsybovsky, Yaroslav, Gulla, Krishana, Gowetski, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923338/
https://www.ncbi.nlm.nih.gov/pubmed/35292666
http://dx.doi.org/10.1038/s41598-022-07485-w
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