Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation

A 79-year-old man suddenly developed right lower extremity (RLE) pain and swelling a few days after receiving his 1st dose of the mRNA-1273 COVID-19 vaccine. Despite this, he proceeded to receive the 2nd dose of his mRNA-1273 COVID-19 vaccine. Investigations confirmed extensive acute deep venous thr...

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Autores principales: Mahgoub, Abdullahi E, Awuah, Dominic, Hussain, MurtazaShabbir, Deliwala, Smit, Bachuwa, Ghassan, Younas, Mariam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923564/
https://www.ncbi.nlm.nih.gov/pubmed/35308698
http://dx.doi.org/10.7759/cureus.22179
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author Mahgoub, Abdullahi E
Awuah, Dominic
Hussain, MurtazaShabbir
Deliwala, Smit
Bachuwa, Ghassan
Younas, Mariam
author_facet Mahgoub, Abdullahi E
Awuah, Dominic
Hussain, MurtazaShabbir
Deliwala, Smit
Bachuwa, Ghassan
Younas, Mariam
author_sort Mahgoub, Abdullahi E
collection PubMed
description A 79-year-old man suddenly developed right lower extremity (RLE) pain and swelling a few days after receiving his 1st dose of the mRNA-1273 COVID-19 vaccine. Despite this, he proceeded to receive the 2nd dose of his mRNA-1273 COVID-19 vaccine. Investigations confirmed extensive acute deep venous thrombosis and a concurrent acute pulmonary embolism. Therapeutic anticoagulation was initiated and he was eventually discharged home on supplemental oxygen. The overall benefits of the vaccine in curbing severe disease overwhelmingly outweigh the handful of cases of reported adverse events. To our knowledge, this is one of the first few cases of provoked venous thrombosis after receiving the mRNA-1273 COVID-19 vaccine during the pharmacovigilance period.
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spelling pubmed-89235642022-03-18 Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation Mahgoub, Abdullahi E Awuah, Dominic Hussain, MurtazaShabbir Deliwala, Smit Bachuwa, Ghassan Younas, Mariam Cureus Internal Medicine A 79-year-old man suddenly developed right lower extremity (RLE) pain and swelling a few days after receiving his 1st dose of the mRNA-1273 COVID-19 vaccine. Despite this, he proceeded to receive the 2nd dose of his mRNA-1273 COVID-19 vaccine. Investigations confirmed extensive acute deep venous thrombosis and a concurrent acute pulmonary embolism. Therapeutic anticoagulation was initiated and he was eventually discharged home on supplemental oxygen. The overall benefits of the vaccine in curbing severe disease overwhelmingly outweigh the handful of cases of reported adverse events. To our knowledge, this is one of the first few cases of provoked venous thrombosis after receiving the mRNA-1273 COVID-19 vaccine during the pharmacovigilance period. Cureus 2022-02-13 /pmc/articles/PMC8923564/ /pubmed/35308698 http://dx.doi.org/10.7759/cureus.22179 Text en Copyright © 2022, Mahgoub et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mahgoub, Abdullahi E
Awuah, Dominic
Hussain, MurtazaShabbir
Deliwala, Smit
Bachuwa, Ghassan
Younas, Mariam
Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title_full Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title_fullStr Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title_full_unstemmed Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title_short Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation
title_sort development of venous thromboembolism after covid-19 mrna-1273 vaccine inoculation
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923564/
https://www.ncbi.nlm.nih.gov/pubmed/35308698
http://dx.doi.org/10.7759/cureus.22179
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