Spine-specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor-positive breast cancer by activating glutamine-dependent mTOR signaling

Estrogen receptor-positive (ER(+)) breast cancer (BC) is a malignancy that is prone to metastasis to the spine, which is difficult to treat and often results in poor prognosis. However, the mechanism underlying the tumorigenesis and spinal metastasis of ER(+) BC remains unclear. Lysosomal protein tr...

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Detalles Bibliográficos
Autores principales: Meng, Qingbing, Zhou, Lei, Liang, Haifeng, Hu, Annan, Zhou, Hao, Zhou, Jian, Zhou, Xiaogang, Lin, Hong, Li, Xilei, Jiang, Libo, Dong, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923652/
https://www.ncbi.nlm.nih.gov/pubmed/35294039
http://dx.doi.org/10.3892/ijo.2022.5337

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