Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition

Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress — a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain pr...

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Detalles Bibliográficos
Autores principales: Peterson, Nicholas D, Icso, Janneke D, Salisbury, J Elizabeth, Rodríguez, Tomás, Thompson, Paul R, Pukkila-Worley, Read
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923663/
https://www.ncbi.nlm.nih.gov/pubmed/35098926
http://dx.doi.org/10.7554/eLife.74206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923663/
https://www.ncbi.nlm.nih.gov/pubmed/35098926
http://dx.doi.org/10.7554/eLife.74206

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