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Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magneti...

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Autores principales: Manea, Ana MG, Zilverstand, Anna, Ugurbil, Kamil, Heilbronner, Sarah R, Zimmermann, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923667/
https://www.ncbi.nlm.nih.gov/pubmed/35234612
http://dx.doi.org/10.7554/eLife.75540
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author Manea, Ana MG
Zilverstand, Anna
Ugurbil, Kamil
Heilbronner, Sarah R
Zimmermann, Jan
author_facet Manea, Ana MG
Zilverstand, Anna
Ugurbil, Kamil
Heilbronner, Sarah R
Zimmermann, Jan
author_sort Manea, Ana MG
collection PubMed
description Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain.
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spelling pubmed-89236672022-03-16 Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain Manea, Ana MG Zilverstand, Anna Ugurbil, Kamil Heilbronner, Sarah R Zimmermann, Jan eLife Neuroscience Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain. eLife Sciences Publications, Ltd 2022-03-02 /pmc/articles/PMC8923667/ /pubmed/35234612 http://dx.doi.org/10.7554/eLife.75540 Text en © 2022, Manea et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Manea, Ana MG
Zilverstand, Anna
Ugurbil, Kamil
Heilbronner, Sarah R
Zimmermann, Jan
Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title_full Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title_fullStr Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title_full_unstemmed Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title_short Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
title_sort intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923667/
https://www.ncbi.nlm.nih.gov/pubmed/35234612
http://dx.doi.org/10.7554/eLife.75540
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