Cargando…

Perspectives for a new drug candidate for Chagas disease therapy

Chagas disease (CD), a neglected tropical illness caused by the protozoan Trypanosoma cruzi, affects more than 6 million people mostly in poor areas of Latin America. CD has two phases: an acute, short phase mainly oligosymptomatic followed to the chronic phase, a long-lasting stage that may trigger...

Descripción completa

Detalles Bibliográficos
Autor principal:	Soeiro, Maria de Nazaré Correia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2022
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923671/ https://www.ncbi.nlm.nih.gov/pubmed/35293439 http://dx.doi.org/10.1590/0074-02760220004

Ejemplares similares

The Centennial of the Discovery of Chagas Disease: Facing the Current Challenges
por: Lannes-Vieira, Joseli, et al.
Publicado: (2010)

Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment
por: de Araujo-Jorge, Tania C, et al.
Publicado: (2022)

Fexinidazole: A Potential New Drug Candidate for Chagas Disease
por: Bahia, Maria Terezinha, et al.
Publicado: (2012)

Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease
por: Timm, Bruno Lisboa, et al.
Publicado: (2023)

Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment
por: Mazzeti, Ana Lia, et al.
Publicado: (2023)

In vitro and in silico analysis of imatinib analogues as anti-Trypanosoma cruzi drug candidates
por: Nesic de Freitas, Luca S. F., et al.
Publicado: (2023)

Economic crisis and increased immigrant mobility: new challenges in managing Chagas disease in Europe
por: Jackson, Yves, et al.
Publicado: (2014)

Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
por: Santi, Ana Maria Murta, et al.
Publicado: (2022)

Genomic surveillance: a potential shortcut for effective Chagas disease management
por: de Azevedo, Sophia Lincoln Cardoso, et al.
Publicado: (2023)

Call for Consensus in the Evaluation of Circulating Matrix Metalloproteinases in Chagas Disease
por: Bautista-López, Norma L., et al.
Publicado: (2022)

Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
por: Waghabi, Mariana Caldas, et al.
Publicado: (2022)

Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
por: Soeiro, Maria de Nazaré C, et al.
Publicado: (2011)

Perspectives on Using Physcomitrella Patens as an Alternative Production Platform for Thapsigargin and Other Terpenoid Drug Candidates
por: Simonsen, Henrik Toft, et al.
Publicado: (2009)

Promoting Safe Early Clinical Research of Novel Drug Candidates: A European Union Regulatory Perspective
por: Ponzano, Stefano, et al.
Publicado: (2017)

Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target
por: Lazarin-Bidóia, Danielle, et al.
Publicado: (2022)

The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates
por: Church, Rachel J., et al.
Publicado: (2020)

New perspectives in iron chelation therapy for the treatment of Parkinson’s disease
por: Nuñez, Marco T., et al.
Publicado: (2019)

Drug Repurposing for COVID-19: A Review and a Novel Strategy to Identify New Targets and Potential Drug Candidates
por: Rodrigues, Liliana, et al.
Publicado: (2022)

7-Aryl-7-deazapurine 3′-deoxyribonucleoside derivative as a novel lead for Chagas’ disease therapy: in vitro and in vivo pharmacology
por: Cardoso-Santos, Camila, et al.
Publicado: (2021)

Anxiety, depression, and memory loss in Chagas disease: a puzzle far beyond neuroinflammation to be unpicked and solved(*)
por: Lannes-Vieira, Joseli, et al.
Publicado: (2023)

A perspective on multi-target drug discovery and design for complex diseases
por: Ramsay, Rona R., et al.
Publicado: (2018)

The gold complex auranofin: new perspectives for cancer therapy
por: Abdalbari, Farah H., et al.
Publicado: (2021)

Surveillance, health promotion and control of Chagas disease in the Amazon Region - Medical attention in the Brazilian Amazon Region: a proposal
por: Coura, José Rodrigues, et al.
Publicado: (2015)

Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives
por: Pawełczyk, Anna, et al.
Publicado: (2020)

Ruthenium Complex with Benznidazole and Nitric Oxide as a New Candidate for the Treatment of Chagas Disease
por: Sesti-Costa, Renata, et al.
Publicado: (2014)

Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention
por: Valenzuela, M, et al.
Publicado: (2012)

Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery
por: Mansoldo, Felipe Raposo Passos, et al.
Publicado: (2020)

New Perspectives on Chronic Obstructive Pulmonary Disease
por: Celli, Bartolome R, et al.
Publicado: (2022)

Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives
por: Pinazo, Maria-Jesus, et al.
Publicado: (2015)

Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?
por: Mattei, César
Publicado: (2018)

Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases: new perspectives
por: Silveira, Gustavo de Bem, et al.
Publicado: (2021)

Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective
por: Perazzolo, Simone, et al.
Publicado: (2021)

Chagas Disease and Domestic Medical Screening Guidance for Newly Arrived Individuals Under a Humanitarian-Based Immigration Status: A Call for Action
por: Agudelo Higuita, Nelson Iván, et al.
Publicado: (2022)

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
por: Walgrave, Hannah, et al.
Publicado: (2021)

Mechanism of action of glycyrrhizin against Plasmodium falciparum
por: Soeiro, Maria de Nazaré Correia, et al.
Publicado: (2021)

From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease
por: Gomes, Daniele Cavalcante, et al.
Publicado: (2023)

Progress in Inherited Retinal Disease Drug Discovery and Development: A Foundation’s Perspective
por: Yerxa, Benjamin
Publicado: (2018)

Looking Forward to New Therapies: A Personal Perspective on the Translational Landscape for Muscular Dystrophies
por: Bushby, Kate
Publicado: (2015)

Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease
por: Gupta, Shivali, et al.
Publicado: (2013)

Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
por: Swat, MJ, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1h0r3vvb44aouifemju440aaut