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Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast

SIGNIFICANCE: In three-dimensional (3D) functional optoacoustic tomography (OAT), wavelength-dependent optical attenuation and nonuniform incident optical fluence limit imaging depth and field of view and can hinder accurate estimation of functional quantities, such as the vascular blood oxygenation...

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Autores principales: Park, Seonyeong, Brooks, Frank J., Villa, Umberto, Su, Richard, Anastasio, Mark A., Oraevsky, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923705/
https://www.ncbi.nlm.nih.gov/pubmed/35293163
http://dx.doi.org/10.1117/1.JBO.27.3.036001
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author Park, Seonyeong
Brooks, Frank J.
Villa, Umberto
Su, Richard
Anastasio, Mark A.
Oraevsky, Alexander A.
author_facet Park, Seonyeong
Brooks, Frank J.
Villa, Umberto
Su, Richard
Anastasio, Mark A.
Oraevsky, Alexander A.
author_sort Park, Seonyeong
collection PubMed
description SIGNIFICANCE: In three-dimensional (3D) functional optoacoustic tomography (OAT), wavelength-dependent optical attenuation and nonuniform incident optical fluence limit imaging depth and field of view and can hinder accurate estimation of functional quantities, such as the vascular blood oxygenation. These limitations hinder OAT of large objects, such as a human female breast. AIM: We aim to develop a measurement-data-driven method for normalization of the optical fluence distribution and to investigate blood vasculature detectability and accuracy for estimating vascular blood oxygenation. APPROACH: The proposed method is based on reasonable assumptions regarding breast anatomy and optical properties. The nonuniform incident optical fluence is estimated based on the illumination geometry in the OAT system, and the depth-dependent optical attenuation is approximated using Beer–Lambert law. RESULTS: Numerical studies demonstrated that the proposed method significantly enhanced blood vessel detectability and improved estimation accuracy of the vascular blood oxygenation from multiwavelength OAT measurements, compared with direct application of spectral linear unmixing without optical fluence compensation. Experimental results showed that the proposed method revealed previously invisible structures in regions deeper than 15 mm and/or near the chest wall. CONCLUSIONS: The proposed method provides a straightforward and computationally inexpensive approximation of wavelength-dependent effective optical attenuation and, thus, enables mitigation of the spectral coloring effect in functional 3D OAT imaging.
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spelling pubmed-89237052022-03-28 Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast Park, Seonyeong Brooks, Frank J. Villa, Umberto Su, Richard Anastasio, Mark A. Oraevsky, Alexander A. J Biomed Opt Imaging SIGNIFICANCE: In three-dimensional (3D) functional optoacoustic tomography (OAT), wavelength-dependent optical attenuation and nonuniform incident optical fluence limit imaging depth and field of view and can hinder accurate estimation of functional quantities, such as the vascular blood oxygenation. These limitations hinder OAT of large objects, such as a human female breast. AIM: We aim to develop a measurement-data-driven method for normalization of the optical fluence distribution and to investigate blood vasculature detectability and accuracy for estimating vascular blood oxygenation. APPROACH: The proposed method is based on reasonable assumptions regarding breast anatomy and optical properties. The nonuniform incident optical fluence is estimated based on the illumination geometry in the OAT system, and the depth-dependent optical attenuation is approximated using Beer–Lambert law. RESULTS: Numerical studies demonstrated that the proposed method significantly enhanced blood vessel detectability and improved estimation accuracy of the vascular blood oxygenation from multiwavelength OAT measurements, compared with direct application of spectral linear unmixing without optical fluence compensation. Experimental results showed that the proposed method revealed previously invisible structures in regions deeper than 15 mm and/or near the chest wall. CONCLUSIONS: The proposed method provides a straightforward and computationally inexpensive approximation of wavelength-dependent effective optical attenuation and, thus, enables mitigation of the spectral coloring effect in functional 3D OAT imaging. Society of Photo-Optical Instrumentation Engineers 2022-03-16 2022-03 /pmc/articles/PMC8923705/ /pubmed/35293163 http://dx.doi.org/10.1117/1.JBO.27.3.036001 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Imaging
Park, Seonyeong
Brooks, Frank J.
Villa, Umberto
Su, Richard
Anastasio, Mark A.
Oraevsky, Alexander A.
Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title_full Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title_fullStr Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title_full_unstemmed Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title_short Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
title_sort normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast
topic Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923705/
https://www.ncbi.nlm.nih.gov/pubmed/35293163
http://dx.doi.org/10.1117/1.JBO.27.3.036001
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