A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP‐1 dual agonist

Glucagon‐like peptide‐1 (GLP‐1) receptor agonists (GLP‐1RAs) and dual GLP‐1/glucagon receptor agonists improve glycaemic control and cause significant weight loss in patients with type 2 diabetes.(1) These effects are driven in part by augmenting glucose‐stimulated insulin release (incretin effect),...

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Detalles Bibliográficos
Autores principales: Bosch, Rolien, Petrone, Marcella, Arends, Rosalin, Vicini, Paolo, Sijbrands, Eric J. G., Hoefman, Sven, Snelder, Nelleke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923724/
https://www.ncbi.nlm.nih.gov/pubmed/34889083
http://dx.doi.org/10.1002/psp4.12752

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