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Quantitative systems pharmacology model for Alzheimer’s disease to predict the effect of aducanumab on brain amyloid

Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory and cognitive function. Dysregulation of the amyloid‐β (Aβ) pathway and amyloid plaque accumulation in the brain are hallmarks of AD. Aducanumab is a human, immunoglobulin gamma 1 monoclonal antibody tar...

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Detalles Bibliográficos
Autores principales:	Lin, Lin, Hua, Fei, Salinas, Cristian, Young, Carissa, Bussiere, Thierry, Apgar, Joshua F., Burke, John M., Kandadi Muralidharan, Kumar, Rajagovindan, Rajasimhan, Nestorov, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923729/ https://www.ncbi.nlm.nih.gov/pubmed/35029320 http://dx.doi.org/10.1002/psp4.12759

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