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Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors

The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological mechanism is more commonly hypertension than that o...

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Autores principales: Toyoda, Kazunori, Koga, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923997/
https://www.ncbi.nlm.nih.gov/pubmed/35260801
http://dx.doi.org/10.1038/s41440-022-00866-8
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author Toyoda, Kazunori
Koga, Masatoshi
author_facet Toyoda, Kazunori
Koga, Masatoshi
author_sort Toyoda, Kazunori
collection PubMed
description The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological mechanism is more commonly hypertension than that of patients in the Western population. A multicenter, prospective, observational study named the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-IntraCerebral Hemorrhage (SAMURAI-ICH) study, involving 211 patients from ten Japanese stroke centers, was performed to elucidate the safety and feasibility of blood pressure lowering to 160 mmHg or less in acute ICH patients using intravenous nicardipine. When we started the study, intravenous nicardipine was not officially approved for hyperacute ICH patients in Japan. The SAMURAI-ICH study was also a pilot study to judge the feasibility of participation by many Japanese investigators in an international, randomized, controlled trial named the Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)−2 trial. The SAMURAI-ICH study, ATACH-2 trial, and their combined individual participant data meta-analysis produced several new interesting findings on how to control blood pressure levels in acute ICH patients. Some of the findings are introduced in the present review article.
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spelling pubmed-89239972022-03-30 Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors Toyoda, Kazunori Koga, Masatoshi Hypertens Res Review Article The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological mechanism is more commonly hypertension than that of patients in the Western population. A multicenter, prospective, observational study named the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-IntraCerebral Hemorrhage (SAMURAI-ICH) study, involving 211 patients from ten Japanese stroke centers, was performed to elucidate the safety and feasibility of blood pressure lowering to 160 mmHg or less in acute ICH patients using intravenous nicardipine. When we started the study, intravenous nicardipine was not officially approved for hyperacute ICH patients in Japan. The SAMURAI-ICH study was also a pilot study to judge the feasibility of participation by many Japanese investigators in an international, randomized, controlled trial named the Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)−2 trial. The SAMURAI-ICH study, ATACH-2 trial, and their combined individual participant data meta-analysis produced several new interesting findings on how to control blood pressure levels in acute ICH patients. Some of the findings are introduced in the present review article. Springer Singapore 2022-03-08 2022 /pmc/articles/PMC8923997/ /pubmed/35260801 http://dx.doi.org/10.1038/s41440-022-00866-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Toyoda, Kazunori
Koga, Masatoshi
Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title_full Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title_fullStr Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title_full_unstemmed Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title_short Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors
title_sort controlling blood pressure soon after intracerebral hemorrhage: the samurai-ich study and its successors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923997/
https://www.ncbi.nlm.nih.gov/pubmed/35260801
http://dx.doi.org/10.1038/s41440-022-00866-8
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