Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PDAC can escape autodigestion by digestive enzymes. Here we show that human PDAC tumour cells use gasdermin E (GSDME), a pore-forming protein, to mediat...

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Detalles Bibliográficos
Autores principales: Lv, Jiadi, Liu, Yuying, Mo, Siqi, Zhou, Yabo, Chen, Fengye, Cheng, Feiran, Li, Cong, Saimi, Dilizhatai, Liu, Mengyu, Zhang, Huafeng, Tang, Ke, Ma, Jingwei, Wang, Zhenfeng, Zhu, Qiangqiang, Tong, Wei-Min, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924000/
https://www.ncbi.nlm.nih.gov/pubmed/35292781
http://dx.doi.org/10.1038/s41556-022-00857-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924000/
https://www.ncbi.nlm.nih.gov/pubmed/35292781
http://dx.doi.org/10.1038/s41556-022-00857-4

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