Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations

LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine protease necessary for proper muscle function. Our previous findings show that CAPN3 deficiency leads to reduced SERCA levels through increased protein degradation. This work investigates the pot...

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Detalles Bibliográficos
Autores principales: Lasa-Elgarresta, Jaione, Mosqueira-Martín, Laura, González-Imaz, Klaudia, Marco-Moreno, Pablo, Gerenu, Gorka, Mamchaoui, Kamel, Mouly, Vincent, López de Munain, Adolfo, Vallejo-Illarramendi, Ainara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924035/
https://www.ncbi.nlm.nih.gov/pubmed/35309930
http://dx.doi.org/10.3389/fcell.2022.822563

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