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Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient Cells

The spindle assembly checkpoint (SAC) is a critical monitoring device in mitosis for the maintenance of genomic stability. Specifically, the SAC complex comprises several factors, including Mad1, Mad2, and Bub1. Ataxia-telangiectasia mutated (ATM) kinase, the crucial regulator in DNA damage response...

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Detalles Bibliográficos
Autores principales:	Wang, Yang, Yu, Tianyu, Han, Yi, He, Yazhi, Song, Yiran, Guo, Leiming, An, Liwei, Yang, Chunying, Wang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924061/ https://www.ncbi.nlm.nih.gov/pubmed/35309941 http://dx.doi.org/10.3389/fcell.2022.817831

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