BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling

Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable...

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Detalles Bibliográficos
Autores principales: Bradbury, Melissa, Borràs, Eva, Castellví, Josep, Méndez, Olga, Sánchez-Iglesias, José Luis, Pérez-Benavente, Assumpció, Gil-Moreno, Antonio, Sabidó, Eduard, Santamaria, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924168/
https://www.ncbi.nlm.nih.gov/pubmed/35292711
http://dx.doi.org/10.1038/s41598-022-08461-0

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