Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Heterotypic amyloid interactions between related protein sequences have been observed in functional and disease amyloids. While sequence homology seems to favour heterotypic amyloid interactions, we have no systematic understanding of the structural rules determining such interactions nor whether th...

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Detalles Bibliográficos
Autores principales: Louros, Nikolaos, Ramakers, Meine, Michiels, Emiel, Konstantoulea, Katerina, Morelli, Chiara, Garcia, Teresa, Moonen, Nele, D’Haeyer, Sam, Goossens, Vera, Thal, Dietmar Rudolf, Audenaert, Dominique, Rousseau, Frederic, Schymkowitz, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924238/
https://www.ncbi.nlm.nih.gov/pubmed/35292653
http://dx.doi.org/10.1038/s41467-022-28955-9

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