MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma

The efficacy of immune checkpoint blockade (ICB) therapy depends on sufficient infiltration and activation of primed tumor-specific cytotoxic T lymphocytes (CTLs) in the tumor microenvironment. However, many tumor types, including osteosarcoma, mainly display immune-desert or immune-excluded phenoty...

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Detalles Bibliográficos
Autores principales: Jiang, Kuo, Zhang, Qianfeng, Fan, Yong, Li, Jia, Zhang, Jitao, Wang, Wentao, Fan, Jinzhu, Guo, Yunshan, Liu, Shichang, Hao, Dingjun, Wang, Yongxiang, Wang, Lei, Shan, Lequn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924240/
https://www.ncbi.nlm.nih.gov/pubmed/35292660
http://dx.doi.org/10.1038/s41420-022-00923-8

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