Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

A central question in mechanobiology is how mechanical forces acting in or on cells are transmitted to mechanically-gated PIEZO channels that convert these forces into biochemical signals. Here we examined the role of the intracellular domains of PIEZO2, which account for 25% of the channel, and dem...

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Detalles Bibliográficos
Autores principales: Verkest, Clement, Schaefer, Irina, Nees, Timo A., Wang, Na, Jegelka, Juri M., Taberner, Francisco J., Lechner, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924262/
https://www.ncbi.nlm.nih.gov/pubmed/35292651
http://dx.doi.org/10.1038/s41467-022-28974-6

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