Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting inner and outer hair cells in newborn mice. To accelerate translation to humans, we now report the feasibility and ef...

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Detalles Bibliográficos
Autores principales: Andres-Mateos, Eva, Landegger, Lukas D., Unzu, Carmen, Phillips, Jean, Lin, Brian M., Dewyer, Nicholas A., Sanmiguel, Julio, Nicolaou, Fotini, Valero, Michelle D., Bourdeu, Kathrin I., Sewell, William F., Beiler, Rudolph J., McKenna, Michael J., Stankovic, Konstantina M., Vandenberghe, Luk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924271/
https://www.ncbi.nlm.nih.gov/pubmed/35292639
http://dx.doi.org/10.1038/s41467-022-28969-3

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