Synthesis of [(11)C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([(11)C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

BACKGROUND: Receptor-interacting protein 1 kinase (RIPK1) is a key enzyme in the regulation of cellular necroptosis. Recently, cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate (PK68, 5) has been developed as a potent inhibitor of RIPK1. Herein, we synthesized [(11)C]car...

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Detalles Bibliográficos
Autores principales: Yamasaki, Tomoteru, Kumata, Katsushi, Hiraishi, Atsuto, Zhang, Yiding, Wakizaka, Hidekatsu, Kurihara, Yusuke, Nengaki, Nobuki, Zhang, Ming-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924334/
https://www.ncbi.nlm.nih.gov/pubmed/35290562
http://dx.doi.org/10.1186/s41181-022-00156-1

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