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ZDQ-0620, a Novel Phosphatidylinositol 3-Kinase Inhibitor, Inhibits Colorectal Carcinoma Cell Proliferation and Suppresses Angiogenesis by Attenuating PI3K/AKT/mTOR Pathway

The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on the importance of the PI3K/AKT pathway in malignancies, we developed a 4-aminoquinazoline derivative, ZDQ-0620, initially en...

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Detalles Bibliográficos
Autores principales:	Qin, Xiaochun, Liu, Mingyue, Xu, Chang, Xing, Bo, Xu, Xiangbo, Wu, Yuting, Ding, Huaiwei, Zhao, Qingchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924359/ https://www.ncbi.nlm.nih.gov/pubmed/35311154 http://dx.doi.org/10.3389/fonc.2022.848952

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