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Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers. One strategy to initiate bnAb responses is to use germline-targeting (GT) immunogens with high affinity to bnAb-class precurso...

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Detalles Bibliográficos
Autores principales:	Lee, Jeong Hyun, Nakao, Catherine, Appel, Michael, Le, Amber, Landais, Elise, Kalyuzhniy, Oleksandr, Hu, Xiaozhen, Liguori, Alessia, Mullen, Tina-Marie, Groschel, Bettina, Abbott, Robert K., Sok, Devin, Schief, William R., Crotty, Shane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924373/ https://www.ncbi.nlm.nih.gov/pubmed/35263576 http://dx.doi.org/10.1016/j.celrep.2022.110485

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