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Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases

The morbidity and mortality of cardiovascular diseases (CVDs) have been increasing year by year all over the world and expanding greatly to the younger population, which becomes the leading causes of death globally that threatens human life safety. Prediction of the occurrence of diseases by using r...

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Autores principales: Ji, Yanjing, Song, Jinyou, Su, Tianhong, Gu, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924404/
https://www.ncbi.nlm.nih.gov/pubmed/35309061
http://dx.doi.org/10.3389/fphys.2022.856298
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author Ji, Yanjing
Song, Jinyou
Su, Tianhong
Gu, Xiaosong
author_facet Ji, Yanjing
Song, Jinyou
Su, Tianhong
Gu, Xiaosong
author_sort Ji, Yanjing
collection PubMed
description The morbidity and mortality of cardiovascular diseases (CVDs) have been increasing year by year all over the world and expanding greatly to the younger population, which becomes the leading causes of death globally that threatens human life safety. Prediction of the occurrence of diseases by using risk related adverse events is crucial for screening and early detection of CVDs. Thus, the discovery of new biomarkers that related to risks of CVDs are of urgent in the field. Retinol-binding protein 4 (RBP4) is a 21-kDa adipokine, mainly secreted by adipocytes. Besides its well-established function in the induction of insulin resistance, it has also been found in recent years to be closely associated with CVDs and other risk factors, such as hypertension, coronary heart disease, heart failure, obesity, and hyperlipidemia. In this review, we mainly focus on the progress of research that establishes the correlation between RBP4 and CVDs and the corresponding major risk factors in recent years.
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spelling pubmed-89244042022-03-17 Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases Ji, Yanjing Song, Jinyou Su, Tianhong Gu, Xiaosong Front Physiol Physiology The morbidity and mortality of cardiovascular diseases (CVDs) have been increasing year by year all over the world and expanding greatly to the younger population, which becomes the leading causes of death globally that threatens human life safety. Prediction of the occurrence of diseases by using risk related adverse events is crucial for screening and early detection of CVDs. Thus, the discovery of new biomarkers that related to risks of CVDs are of urgent in the field. Retinol-binding protein 4 (RBP4) is a 21-kDa adipokine, mainly secreted by adipocytes. Besides its well-established function in the induction of insulin resistance, it has also been found in recent years to be closely associated with CVDs and other risk factors, such as hypertension, coronary heart disease, heart failure, obesity, and hyperlipidemia. In this review, we mainly focus on the progress of research that establishes the correlation between RBP4 and CVDs and the corresponding major risk factors in recent years. Frontiers Media S.A. 2022-03-02 /pmc/articles/PMC8924404/ /pubmed/35309061 http://dx.doi.org/10.3389/fphys.2022.856298 Text en Copyright © 2022 Ji, Song, Su and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ji, Yanjing
Song, Jinyou
Su, Tianhong
Gu, Xiaosong
Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title_full Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title_fullStr Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title_full_unstemmed Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title_short Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases
title_sort adipokine retinol binding protein 4 and cardiovascular diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924404/
https://www.ncbi.nlm.nih.gov/pubmed/35309061
http://dx.doi.org/10.3389/fphys.2022.856298
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