SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC

UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles of SLC35B4 in hepatocellular carcinoma (HCC) tum...

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Autores principales: Jiang, Tao, Yang, Jinghong, Yang, Huohong, Chen, Wancheng, Ji, Kaiyuan, Xu, Yang, Yu, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924407/
https://www.ncbi.nlm.nih.gov/pubmed/35308201
http://dx.doi.org/10.3389/fphar.2022.851089
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author Jiang, Tao
Yang, Jinghong
Yang, Huohong
Chen, Wancheng
Ji, Kaiyuan
Xu, Yang
Yu, Lili
author_facet Jiang, Tao
Yang, Jinghong
Yang, Huohong
Chen, Wancheng
Ji, Kaiyuan
Xu, Yang
Yu, Lili
author_sort Jiang, Tao
collection PubMed
description UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles of SLC35B4 in hepatocellular carcinoma (HCC) tumorigenesis remain unknown. We find that the expression levels of SLC35B4 are higher in HCC tissues than adjacent non-tumor tissues. SLC35B4 is important for the proliferation and tumorigenesis of HCC cells. Mechanistically, SLC35B4 is important for the O-GlcNAc modification of c-Myc and thus the stabilization of c-Myc, which is required for HCC tumorigenesis. Therefore, SLC35B4 is a promising therapeutic target for treating HCC.
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spelling pubmed-89244072022-03-17 SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC Jiang, Tao Yang, Jinghong Yang, Huohong Chen, Wancheng Ji, Kaiyuan Xu, Yang Yu, Lili Front Pharmacol Pharmacology UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles of SLC35B4 in hepatocellular carcinoma (HCC) tumorigenesis remain unknown. We find that the expression levels of SLC35B4 are higher in HCC tissues than adjacent non-tumor tissues. SLC35B4 is important for the proliferation and tumorigenesis of HCC cells. Mechanistically, SLC35B4 is important for the O-GlcNAc modification of c-Myc and thus the stabilization of c-Myc, which is required for HCC tumorigenesis. Therefore, SLC35B4 is a promising therapeutic target for treating HCC. Frontiers Media S.A. 2022-03-02 /pmc/articles/PMC8924407/ /pubmed/35308201 http://dx.doi.org/10.3389/fphar.2022.851089 Text en Copyright © 2022 Jiang, Yang, Yang, Chen, Ji, Xu and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jiang, Tao
Yang, Jinghong
Yang, Huohong
Chen, Wancheng
Ji, Kaiyuan
Xu, Yang
Yu, Lili
SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title_full SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title_fullStr SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title_full_unstemmed SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title_short SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
title_sort slc35b4 stabilizes c-myc protein by o-glcnacylation in hcc
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924407/
https://www.ncbi.nlm.nih.gov/pubmed/35308201
http://dx.doi.org/10.3389/fphar.2022.851089
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