Cargando…

Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital

Studies specifically designed to determine the profile of psychiatric symptoms among COVID-19 patients are limited and based on case series, self-report questionnaires, and surveys. The objective of the study was to identify and classify the neuropsychological symptoms of hospitalized COVID-19 patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Molina, Juan D., Rodrigo Holgado, Irene, Juanes González, Alba, Combarro Ripoll, Carolina Elisa, Lora Pablos, David, Rubio, Gabriel, Alonso, Jordi, Rivas-Clemente, Francisco P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924474/
https://www.ncbi.nlm.nih.gov/pubmed/35308888
http://dx.doi.org/10.3389/fpsyt.2022.838239
_version_ 1784669863941242880
author Molina, Juan D.
Rodrigo Holgado, Irene
Juanes González, Alba
Combarro Ripoll, Carolina Elisa
Lora Pablos, David
Rubio, Gabriel
Alonso, Jordi
Rivas-Clemente, Francisco P. J.
author_facet Molina, Juan D.
Rodrigo Holgado, Irene
Juanes González, Alba
Combarro Ripoll, Carolina Elisa
Lora Pablos, David
Rubio, Gabriel
Alonso, Jordi
Rivas-Clemente, Francisco P. J.
author_sort Molina, Juan D.
collection PubMed
description Studies specifically designed to determine the profile of psychiatric symptoms among COVID-19 patients are limited and based on case series, self-report questionnaires, and surveys. The objective of the study was to identify and classify the neuropsychological symptoms of hospitalized COVID-19 patients during the first wave of the pandemic in one of the most important front-line tertiary hospitals from Spain, and to analyze its correlation with diagnosed mental disorders, as well as to explore potential risk factors associated with mental health problems. This observational, cohort study involved data from COVID-19 patients at the University Hospital 12 de Octubre (Madrid, Spain) from February to May 2020. First, patients underwent a semistructured phone interview (screening phase), based on the Mini International Neuropsychiatric Interview (MINI). Then the confirmation of the diagnosis (confirmation phase) was performed in patients who reported a mental disorder development or worsening. A factorial analysis was performed to identify groups of symptoms. A tetrachoric matrix was created, and factorial analysis, by a principal component analysis, was employed upon it. Factors showing values >1.0 were selected, and a varimax rotation was applied to these factors. Symptoms most frequently identified in patients were anosmia/ageusia (54.6%), cognitive complaints (50.3%), worry/nervousness (43.8%), slowing down (36.2%), and sadness (35.4%). Four factors were identified after the screening phase. The first (“anxiety/depression”) and second (“executive dysfunction”) factors explained 45.4 and 11.5% of the variance, respectively. Women, age between 50 and 60 years, duration in the hospital (more than 13 days), and psychiatric history showed significant higher levels (number of symptoms) in the factors. This study reports the factor structure of the psychiatric symptoms developed by patients with a confirmed diagnosis of SARS-CoV2 during the first wave of the COVID-19. Three item domains (anxiety, depression, and posttraumatic stress disorder symptoms) were loaded together on one factor, whereas sleep disturbance stood up as a separate factor. Interestingly, the item anosmia/ageusia was not captured by any factor. In conclusion, an increase in neuropsychiatric morbidity is expected in the upcoming months and years. Therefore, screening for early symptoms is the first step to prevent mental health problems associated with this pandemic.
format Online
Article
Text
id pubmed-8924474
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89244742022-03-17 Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital Molina, Juan D. Rodrigo Holgado, Irene Juanes González, Alba Combarro Ripoll, Carolina Elisa Lora Pablos, David Rubio, Gabriel Alonso, Jordi Rivas-Clemente, Francisco P. J. Front Psychiatry Psychiatry Studies specifically designed to determine the profile of psychiatric symptoms among COVID-19 patients are limited and based on case series, self-report questionnaires, and surveys. The objective of the study was to identify and classify the neuropsychological symptoms of hospitalized COVID-19 patients during the first wave of the pandemic in one of the most important front-line tertiary hospitals from Spain, and to analyze its correlation with diagnosed mental disorders, as well as to explore potential risk factors associated with mental health problems. This observational, cohort study involved data from COVID-19 patients at the University Hospital 12 de Octubre (Madrid, Spain) from February to May 2020. First, patients underwent a semistructured phone interview (screening phase), based on the Mini International Neuropsychiatric Interview (MINI). Then the confirmation of the diagnosis (confirmation phase) was performed in patients who reported a mental disorder development or worsening. A factorial analysis was performed to identify groups of symptoms. A tetrachoric matrix was created, and factorial analysis, by a principal component analysis, was employed upon it. Factors showing values >1.0 were selected, and a varimax rotation was applied to these factors. Symptoms most frequently identified in patients were anosmia/ageusia (54.6%), cognitive complaints (50.3%), worry/nervousness (43.8%), slowing down (36.2%), and sadness (35.4%). Four factors were identified after the screening phase. The first (“anxiety/depression”) and second (“executive dysfunction”) factors explained 45.4 and 11.5% of the variance, respectively. Women, age between 50 and 60 years, duration in the hospital (more than 13 days), and psychiatric history showed significant higher levels (number of symptoms) in the factors. This study reports the factor structure of the psychiatric symptoms developed by patients with a confirmed diagnosis of SARS-CoV2 during the first wave of the COVID-19. Three item domains (anxiety, depression, and posttraumatic stress disorder symptoms) were loaded together on one factor, whereas sleep disturbance stood up as a separate factor. Interestingly, the item anosmia/ageusia was not captured by any factor. In conclusion, an increase in neuropsychiatric morbidity is expected in the upcoming months and years. Therefore, screening for early symptoms is the first step to prevent mental health problems associated with this pandemic. Frontiers Media S.A. 2022-03-02 /pmc/articles/PMC8924474/ /pubmed/35308888 http://dx.doi.org/10.3389/fpsyt.2022.838239 Text en Copyright © 2022 Molina, Rodrigo Holgado, Juanes González, Combarro Ripoll, Lora Pablos, Rubio, Alonso and Rivas-Clemente. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Molina, Juan D.
Rodrigo Holgado, Irene
Juanes González, Alba
Combarro Ripoll, Carolina Elisa
Lora Pablos, David
Rubio, Gabriel
Alonso, Jordi
Rivas-Clemente, Francisco P. J.
Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title_full Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title_fullStr Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title_full_unstemmed Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title_short Neuropsychological Symptom Identification and Classification in the Hospitalized COVID-19 Patients During the First Wave of the Pandemic in a Front-Line Spanish Tertiary Hospital
title_sort neuropsychological symptom identification and classification in the hospitalized covid-19 patients during the first wave of the pandemic in a front-line spanish tertiary hospital
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924474/
https://www.ncbi.nlm.nih.gov/pubmed/35308888
http://dx.doi.org/10.3389/fpsyt.2022.838239
work_keys_str_mv AT molinajuand neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT rodrigoholgadoirene neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT juanesgonzalezalba neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT combarroripollcarolinaelisa neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT lorapablosdavid neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT rubiogabriel neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT alonsojordi neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital
AT rivasclementefranciscopj neuropsychologicalsymptomidentificationandclassificationinthehospitalizedcovid19patientsduringthefirstwaveofthepandemicinafrontlinespanishtertiaryhospital