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KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma
OBJECTIVE: Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeli...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924484/ https://www.ncbi.nlm.nih.gov/pubmed/35311227 http://dx.doi.org/10.3389/fendo.2022.830130 |
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author | Lee, Bo-Ching Kang, Victor Jing-Wei Pan, Chien-Ting Huang, Jia-Zheng Lin, Yu-Li Chang, Yi-Yao Tsai, Cheng-Hsuan Chou, Chia-Hung Chen, Zheng-Wei Liao, Che-Wei Chiu, Yu-Wei Wu, Vin-Cent Hung, Chi-Sheng Chang, Chin-Chen Lin, Yen-Hung |
author_facet | Lee, Bo-Ching Kang, Victor Jing-Wei Pan, Chien-Ting Huang, Jia-Zheng Lin, Yu-Li Chang, Yi-Yao Tsai, Cheng-Hsuan Chou, Chia-Hung Chen, Zheng-Wei Liao, Che-Wei Chiu, Yu-Wei Wu, Vin-Cent Hung, Chi-Sheng Chang, Chin-Chen Lin, Yen-Hung |
author_sort | Lee, Bo-Ching |
collection | PubMed |
description | OBJECTIVE: Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status. METHODS: We enrolled 179 APA patients who had undergone adrenalectomy from a prospectively maintained database, of whom 99 had KCNJ5 somatic mutations. Preoperative clinical, biochemical and imaging data of abdominal CT, including abdominal aortic calcification (AAC) score, aortic diameter and wall thickness at levels of superior (SMA) and inferior (IMA) mesenteric arteries were analyzed. RESULTS: After propensity score matching for age, sex, body mass index, triglycerides and low-density lipoprotein, there were 48 patients in each KCNJ5 (+) and KCNJ5 (-) group. Mutation carriers had a lower AAC score (217.3 ± 562.2 vs. 605.6 ± 1359.1, P=0.018), higher aortic wall thickness (SMA level: 2.2 ± 0.6 mm vs. 1.8 ± 0.6 mm, P=0.006; IMA level: 2.4 ± 0.6 mm vs. 1.8 ± 0.7 mm, P<0.001) than non-carriers. In multivariate analysis, KCNJ5 mutations were independently associated with AAC score (P=0.014) and aortic wall thickness (SMA level: P<0.001; IMA level: P=0.004). After adrenalectomy, mutation carriers had less aortic wall thickness progression than non-carriers (Δthickness SMA: -0.1 ± 0.8 mm vs. 0.9 ± 0.6 mm, P=0.024; IMA: -0.1 ± 0.6 mm vs. 0.8 ± 0.7 mm, P=0.04). CONCLUSION: KCNJ5 mutation carriers had less calcification burden of the aorta, thickened aortic wall, and less wall thickness progression than non-carriers. |
format | Online Article Text |
id | pubmed-8924484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89244842022-03-17 KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma Lee, Bo-Ching Kang, Victor Jing-Wei Pan, Chien-Ting Huang, Jia-Zheng Lin, Yu-Li Chang, Yi-Yao Tsai, Cheng-Hsuan Chou, Chia-Hung Chen, Zheng-Wei Liao, Che-Wei Chiu, Yu-Wei Wu, Vin-Cent Hung, Chi-Sheng Chang, Chin-Chen Lin, Yen-Hung Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status. METHODS: We enrolled 179 APA patients who had undergone adrenalectomy from a prospectively maintained database, of whom 99 had KCNJ5 somatic mutations. Preoperative clinical, biochemical and imaging data of abdominal CT, including abdominal aortic calcification (AAC) score, aortic diameter and wall thickness at levels of superior (SMA) and inferior (IMA) mesenteric arteries were analyzed. RESULTS: After propensity score matching for age, sex, body mass index, triglycerides and low-density lipoprotein, there were 48 patients in each KCNJ5 (+) and KCNJ5 (-) group. Mutation carriers had a lower AAC score (217.3 ± 562.2 vs. 605.6 ± 1359.1, P=0.018), higher aortic wall thickness (SMA level: 2.2 ± 0.6 mm vs. 1.8 ± 0.6 mm, P=0.006; IMA level: 2.4 ± 0.6 mm vs. 1.8 ± 0.7 mm, P<0.001) than non-carriers. In multivariate analysis, KCNJ5 mutations were independently associated with AAC score (P=0.014) and aortic wall thickness (SMA level: P<0.001; IMA level: P=0.004). After adrenalectomy, mutation carriers had less aortic wall thickness progression than non-carriers (Δthickness SMA: -0.1 ± 0.8 mm vs. 0.9 ± 0.6 mm, P=0.024; IMA: -0.1 ± 0.6 mm vs. 0.8 ± 0.7 mm, P=0.04). CONCLUSION: KCNJ5 mutation carriers had less calcification burden of the aorta, thickened aortic wall, and less wall thickness progression than non-carriers. Frontiers Media S.A. 2022-03-02 /pmc/articles/PMC8924484/ /pubmed/35311227 http://dx.doi.org/10.3389/fendo.2022.830130 Text en Copyright © 2022 Lee, Kang, Pan, Huang, Lin, Chang, Tsai, Chou, Chen, Liao, Chiu, Wu, Hung, Chang and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Lee, Bo-Ching Kang, Victor Jing-Wei Pan, Chien-Ting Huang, Jia-Zheng Lin, Yu-Li Chang, Yi-Yao Tsai, Cheng-Hsuan Chou, Chia-Hung Chen, Zheng-Wei Liao, Che-Wei Chiu, Yu-Wei Wu, Vin-Cent Hung, Chi-Sheng Chang, Chin-Chen Lin, Yen-Hung KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title | KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title_full | KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title_fullStr | KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title_full_unstemmed | KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title_short | KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma |
title_sort | kcnj5 somatic mutation is associated with higher aortic wall thickness and less calcification in patients with aldosterone-producing adenoma |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924484/ https://www.ncbi.nlm.nih.gov/pubmed/35311227 http://dx.doi.org/10.3389/fendo.2022.830130 |
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