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Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment

ABO blood group antibodies have not been generated or are at low titer during early infancy. Therefore, in theory, ABO-incompatible kidney transplantation (ABOi KT) may be successfully achieved in small infants without any pre-transplant treatment. We report here the first ABO-incompatible deceased...

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Autores principales: Zhao, Daqiang, Zhu, Lan, Zhang, Shengyuan, Guo, Zhiliang, Wang, Lu, Pan, Tianhui, Sa, Rula, Chen, Zhishui, Jiang, Jipin, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924516/
https://www.ncbi.nlm.nih.gov/pubmed/35308516
http://dx.doi.org/10.3389/fmed.2022.838738
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author Zhao, Daqiang
Zhu, Lan
Zhang, Shengyuan
Guo, Zhiliang
Wang, Lu
Pan, Tianhui
Sa, Rula
Chen, Zhishui
Jiang, Jipin
Chen, Gang
author_facet Zhao, Daqiang
Zhu, Lan
Zhang, Shengyuan
Guo, Zhiliang
Wang, Lu
Pan, Tianhui
Sa, Rula
Chen, Zhishui
Jiang, Jipin
Chen, Gang
author_sort Zhao, Daqiang
collection PubMed
description ABO blood group antibodies have not been generated or are at low titer during early infancy. Therefore, in theory, ABO-incompatible kidney transplantation (ABOi KT) may be successfully achieved in small infants without any pre-transplant treatment. We report here the first ABO-incompatible deceased donor kidney transplantation (ABOi DDKT) in an infant. The recipient infant was ABO blood group O, and the donor group A. The recipient was diagnosed with a Wilms tumor gene 1 (WT1) mutation and had received peritoneal dialysis for 4 months prior to transplant. At 7 months and 27 days of age, the infant underwent bilateral native nephrectomy and single-kidney transplantation from a 3-year-old brain-dead donor. No pre- or post-transplantation antibody removal treatment was performed, since the recipient's anti-iso-hemagglutinin-A Ig-M/G antibody titers were both low (1:2) before transplantation and have remained at low levels or undetectable to date. At 11 months post-transplant, the recipient is at home, thriving, with normal development and graft function. This outcome suggests that ABOi DDKT without antibody removal preparatory treatment is feasible in small infants, providing a new option for kidney transplantation in this age range.
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spelling pubmed-89245162022-03-17 Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment Zhao, Daqiang Zhu, Lan Zhang, Shengyuan Guo, Zhiliang Wang, Lu Pan, Tianhui Sa, Rula Chen, Zhishui Jiang, Jipin Chen, Gang Front Med (Lausanne) Medicine ABO blood group antibodies have not been generated or are at low titer during early infancy. Therefore, in theory, ABO-incompatible kidney transplantation (ABOi KT) may be successfully achieved in small infants without any pre-transplant treatment. We report here the first ABO-incompatible deceased donor kidney transplantation (ABOi DDKT) in an infant. The recipient infant was ABO blood group O, and the donor group A. The recipient was diagnosed with a Wilms tumor gene 1 (WT1) mutation and had received peritoneal dialysis for 4 months prior to transplant. At 7 months and 27 days of age, the infant underwent bilateral native nephrectomy and single-kidney transplantation from a 3-year-old brain-dead donor. No pre- or post-transplantation antibody removal treatment was performed, since the recipient's anti-iso-hemagglutinin-A Ig-M/G antibody titers were both low (1:2) before transplantation and have remained at low levels or undetectable to date. At 11 months post-transplant, the recipient is at home, thriving, with normal development and graft function. This outcome suggests that ABOi DDKT without antibody removal preparatory treatment is feasible in small infants, providing a new option for kidney transplantation in this age range. Frontiers Media S.A. 2022-03-02 /pmc/articles/PMC8924516/ /pubmed/35308516 http://dx.doi.org/10.3389/fmed.2022.838738 Text en Copyright © 2022 Zhao, Zhu, Zhang, Guo, Wang, Pan, Sa, Chen, Jiang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhao, Daqiang
Zhu, Lan
Zhang, Shengyuan
Guo, Zhiliang
Wang, Lu
Pan, Tianhui
Sa, Rula
Chen, Zhishui
Jiang, Jipin
Chen, Gang
Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title_full Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title_fullStr Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title_full_unstemmed Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title_short Case Report: Successful ABO-Incompatible Deceased Donor Kidney Transplantation in an Infant Without Pre-transplant Immunological Treatment
title_sort case report: successful abo-incompatible deceased donor kidney transplantation in an infant without pre-transplant immunological treatment
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924516/
https://www.ncbi.nlm.nih.gov/pubmed/35308516
http://dx.doi.org/10.3389/fmed.2022.838738
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